Methadone hydrochloride and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methadone hydrochloride (methadone hydrochloride) and Reglan (metoclopramide hydrochloride). Common drug interactions include emotional distress among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Methadone hydrochloride and Reglan. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Methadone hydrochloride?

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 8,598 Methadone hydrochloride users. Check the latest studies of Methadone hydrochloride.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

On Jul, 10, 2026

45 people who take Methadone hydrochloride and Reglan together, and have interactions are studied.

Methadone hydrochloride and Reglan drug interactions.

What are the common drug interactions of Methadone Hydrochloride and Reglan, by gender? *:

female:

Emotional distress
Impaired gastric emptying
Intervertebral disc degeneration (spinal disc degeneration)
Oedema (fluid collection in tissue)
Osteonecrosis of jaw (death of bone of jaw)
Tooth loss
Asthma
Back pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

male:

Dehydration (dryness resulting from the removal of water)
Generalised oedema (swelling all over the body)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic failure (liver failure)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Infusion related reaction
Malignant neoplasm progression (cancer tumour came back)
Migraine (headache)

What are the common drug interactions of Methadone Hydrochloride and Reglan, by age (0-1 to 60+)? *:

0-1:

Capillary leak syndrome (capillary leaks plasma)
Hypotension (abnormally low blood pressure)

2-9:

n/a

10-19:

Alanine aminotransferase increased
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Autoimmune hepatitis
Blood alkaline phosphatase increased
Breath sounds
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dry eye (lack of adequate tears)

20-29:

Adverse reaction
Anxiety
Arthralgia (joint pain)
Hallucination (an experience involving the perception of something not present)
Lymphadenopathy (disease or enlargement of lymph nodes)
Pain in extremity
Restlessness (not able to rest)
Tendonitis (a condition that causes pain and swelling of tendons)

30-39:

Contusion (a type of hematoma of tissue in which capillaries)
Vomiting
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Generalised oedema (swelling all over the body)
Mobility decreased (ability to move is reduced)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)

40-49:

Impaired gastric emptying
Activities of daily living impaired
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Adrenal disorder
Anxiety
Atelectasis (partial or complete collapse of the lung)
Bone loss
Cardiac failure congestive
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

50-59:

Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Oropharyngeal pain
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Anaemia of chronic disease
Arteriosclerosis (thickening and hardening of arteries)
Asthma
Blood pressure decreased
Chest discomfort
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Osteomyelitis (infection of bone)
Pain in jaw
Skin irritation
Surgery
Tooth extraction
Vein disorder
Actinomycosis (infection that causes sores, or abscesses)
Back pain

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 6 people, 13.33%
Abdominal Pain: 6 people, 13.33%
Urinary Tract Infection: 5 people, 11.11%
Pancreatic Carcinoma Metastatic (pancreatic cancer- metastatic): 5 people, 11.11%
Dyspnea (difficult or laboured breathing): 5 people, 11.11%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 5 people, 11.11%
Adenocarcinoma Pancreas (cancer of pancreas): 5 people, 11.11%
Stress And Anxiety: 4 people, 8.89%
High Blood Pressure: 4 people, 8.89%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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