Methadone hydrochloride and Risperdal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methadone hydrochloride (methadone hydrochloride) and Risperdal (risperidone). Common drug interactions include blood alkaline phosphatase increased among females and delusion among males.

The phase IV clinical study analyzes what interactions people have when they take Methadone hydrochloride and Risperdal. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Methadone hydrochloride?

Methadone hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 8,598 Methadone hydrochloride users. Check the latest studies of Methadone hydrochloride.

What is Risperdal?

Risperdal has active ingredients of risperidone. It is often used in bipolar disorder. eHealthMe is studying from 127,729 Risperdal users. Check the latest studies of Risperdal.

On Jul, 15, 2026

25 people who take Methadone hydrochloride and Risperdal together, and have interactions are studied.

Methadone hydrochloride and Risperdal drug interactions.

What are the common drug interactions of Methadone Hydrochloride and Risperdal, by gender? *:

female:

Blood alkaline phosphatase increased
Blood cholesterol increased
Blood triglycerides increased
Blood urea increased
Dementia (madness)
Diabetes mellitus inadequate control
Diabetic eye disease
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)

male:

Delusion (a false belief or opinion)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Antisocial personality disorder
Anxiety
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Arthralgia (joint pain)
Back pain
Bladder outlet obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded)
Brain injury
Cardiac failure congestive

What are the common drug interactions of Methadone Hydrochloride and Risperdal, by age (0-1 to 60+)? *:

0-1:

Capillary leak syndrome (capillary leaks plasma)
Hypotension (abnormally low blood pressure)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Antisocial personality disorder
Delusion (a false belief or opinion)
Drug dependence
Hallucination, auditory (perceiving sounds without auditory stimulus)
Psychotic disorder
Suicidal ideation
Aspartate aminotransferase increased
Bladder spasm
Blood alkaline phosphatase increased
Blood cholesterol increased

40-49:

Pleural effusion (water on the lungs)
Pneumonia
Depressed level of consciousness
Respiratory depression (respiration has a rate below 12 breaths)
Dementia (madness)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Fear
Hallucination (an experience involving the perception of something not present)
Hyperglycaemia (high blood sugar)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)

50-59:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperglycaemia (high blood sugar)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Nausea (feeling of having an urge to vomit)
Type 2 diabetes mellitus
Arthralgia (joint pain)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control

60+:

Acute prerenal failure (prerenal acute renal failure (arf) occurs when a sudden reduction in blood flow to the kidney)
Anaemia (lack of blood)
Cerebral haemorrhage (bleeding within the brain)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Exposed bone in jaw
Gait disturbance
Gingival bleeding (bleeding gums)
Gout (uric acid crystals building up in the body)
Hyperlipidaemia (presence of excess lipids in the blood)

What are the existing conditions these people have? *

Stress And Anxiety: 9 people, 36.00%
Affective Disorder (mental disorder): 7 people, 28.00%
High Blood Pressure: 6 people, 24.00%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 5 people, 20.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 20.00%
Depression: 5 people, 20.00%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 5 people, 20.00%
Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 5 people, 20.00%
Mania (a state of abnormally elevated or irritable mood): 5 people, 20.00%
Oedema Peripheral (superficial swelling): 5 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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