Methergine and Augmentin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methergine (methylergonovine maleate) and Augmentin (amoxicillin; clavulanate potassium). Common drug interactions include pyrexia among females and atelectasis among males.

The phase IV clinical study analyzes what interactions people have when they take Methergine and Augmentin. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Methergine?

Methergine has active ingredients of methylergonovine maleate. It is often used in migraine. eHealthMe is studying from 999 Methergine users. Check the latest studies of Methergine.

What is Augmentin?

Augmentin has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 42,620 Augmentin users. Check the latest studies of Augmentin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

14 people who take Methergine and Augmentin together, and have interactions are studied.

Methergine and Augmentin drug interactions.

What are the common drug interactions of Methergine and Augmentin, by gender? *:

female:

Pyrexia (fever)
Vomiting
Abortion spontaneous (naturally occurring miscarriage)
Acute respiratory distress syndrome
Anxiety
Circulatory collapse
Cough
Depressed level of consciousness
Depression
Drug ineffective

male:

Atelectasis (partial or complete collapse of the lung)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Suicide attempt
Neonatal respiratory distress syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)
Otitis media chronic (long lasting inflammation of the middle ear)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Post procedural complication
Transposition of the great vessels
Yellow skin
Agitation (state of anxiety or nervous excitement)

What are the common drug interactions of Methergine and Augmentin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Vomiting
Depressed level of consciousness
Encephalitis (inflammation of the brain)
Loss of consciousness
Nausea (feeling of having an urge to vomit)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Abortion spontaneous (naturally occurring miscarriage)
Agitation (state of anxiety or nervous excitement)
Anxiety
Blood pressure fluctuation

30-39:

Abortion spontaneous (naturally occurring miscarriage)
Anxiety
Complication of pregnancy
Depression
Drug addiction
Drug ineffective
Emotional distress
Injury
Pain
Pelvic inflammatory disease

40-49:

Pyrexia (fever)
Acute respiratory distress syndrome
Circulatory collapse
Cough
Dyspnoea (difficult or laboured respiration)
Hyperthermia (body temperature greatly above normal)
Hypoxia (low oxygen in tissues)
Inflammation
Influenza serology positive
Interstitial lung disease

50-59:

Coma (state of unconsciousness lasting more than six hours)
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Bradycardia (abnormally slow heart action)
Cardiac arrest

60+:

Atelectasis (partial or complete collapse of the lung)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Neonatal respiratory distress syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)
Otitis media chronic (long lasting inflammation of the middle ear)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Post procedural complication
Transposition of the great vessels
Yellow skin

What are the existing conditions these people have? *

Vaginal Bleeding Between Periods: 2 people, 14.29%
Haemochromatosis (body to absorb more iron than usual from food): 2 people, 14.29%
Birth Control: 2 people, 14.29%
Stress And Anxiety: 1 person, 7.14%
Premenstrual Dysphoric Disorder: 1 person, 7.14%
Pain In Jaw: 1 person, 7.14%
Heavy Or Prolong Menstrual Bleeding: 1 person, 7.14%
Depression: 1 person, 7.14%
Acute Tonsillitis: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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