Methocarbamol and Lotrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methocarbamol (methocarbamol) and Lotrel (amlodipine besylate; benazepril hydrochloride). Common drug interactions include chest pain among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Methocarbamol and Lotrel. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Methocarbamol?

Methocarbamol has active ingredients of methocarbamol. It is often used in muscle spasms. eHealthMe is studying from 17,766 Methocarbamol users. Check the latest studies of Methocarbamol.

What is Lotrel?

Lotrel has active ingredients of amlodipine besylate; benazepril hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 13,571 Lotrel users. Check the latest studies of Lotrel.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

81 people who take Methocarbamol and Lotrel together, and have interactions are studied.

Methocarbamol and Lotrel drug interactions.

What are the common drug interactions of Methocarbamol and Lotrel, by gender? *:

female:

Chest pain
Cystitis interstitial (unknown cause characterized by bladder pain)
Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth)
Depression
Diplopia (double vision)
Dizziness
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Essential hypertension (primary hypertension)
Fatigue (feeling of tiredness)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Chest pain
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Erythema (redness of the skin)
Flushing (the warm, red condition of human skin)
Gastroenteritis helicobacter (inflammation of stomach and intestine caused by helicobacter infection)
Hypoaesthesia (reduced sense of touch or sensation)
Pneumonia
Pyrexia (fever)

What are the common drug interactions of Methocarbamol and Lotrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asthenia (weakness)
Back injury
Back pain
Biliary tract disorder
Body temperature increased
Dehydration (dryness resulting from the removal of water)
Depression

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Nephrogenic anaemia (anaemia due to kidney disease)
Accidental needle stick
Amyloidosis (a tumour within which amyloid is produced)
Bone disorder
Chest pain
Death
Depression

50-59:

Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Dysgeusia (disorder of the sense of taste)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematuria (presence of blood in urine)
Inflammation
Knee arthroplasty
Lip swelling
Mean cell haemoglobin concentration decreased (less concentration of haemoglobin in a given volume of packed red blood cells)

60+:

Diarrhoea
Flushing (the warm, red condition of human skin)
Alanine aminotransferase decreased
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety
Ataxia (loss of full control of bodily movements)
Blood potassium decreased
Blood urea nitrogen/creatinine ratio increased
Chest discomfort
Diplopia (double vision)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 28 people, 34.57%
Stress And Anxiety: 20 people, 24.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 16 people, 19.75%
Pain: 16 people, 19.75%
Chest Pain: 15 people, 18.52%
Depression: 14 people, 17.28%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 12 people, 14.81%
Neuralgia (pain in one or more nerves): 12 people, 14.81%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 14.81%
Nausea (feeling of having an urge to vomit): 11 people, 13.58%

* Approximation only. Some reports may have incomplete information.

Do you take Methocarbamol and Lotrel?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously