Methocarbamol and Tylenol w/ codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methocarbamol (methocarbamol) and Tylenol w/ codeine (acetaminophen; codeine phosphate). Common drug interactions include cholelithiasis among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Methocarbamol and Tylenol w/ codeine. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Methocarbamol?

Methocarbamol has active ingredients of methocarbamol. It is often used in muscle spasms. eHealthMe is studying from 17,766 Methocarbamol users. Check the latest studies of Methocarbamol.

What is Tylenol w/ codeine?

Tylenol w/ codeine has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 8,107 Tylenol w/ codeine users. Check the latest studies of Tylenol w/ codeine.

On Jul, 06, 2026

60 people who take Methocarbamol and Tylenol w/ codeine together, and have interactions are studied.

Methocarbamol and Tylenol w/ codeine drug interactions.

What are the common drug interactions of Methocarbamol and Tylenol W/ Codeine, by gender? *:

female:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Constipation
Coordination abnormal (abnormal movement)
Cough
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dependence
Depression suicidal (suicide depressive disorder)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

male:

Drug ineffective
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Feeling cold
Femur fracture
Hypoaesthesia (reduced sense of touch or sensation)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Insomnia (sleeplessness)
International normalised ratio decreased
International normalised ratio increased
Lacrimation increased

What are the common drug interactions of Methocarbamol and Tylenol W/ Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug addiction
Self-injurious ideation
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hypersensitivity
Hypertension (high blood pressure)
Injury
Mobility decreased (ability to move is reduced)

30-39:

Dyspnoea (difficult or laboured respiration)
Infusion related reaction
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Hypoperfusion (decreased blood flow through an organ)
Nausea (feeling of having an urge to vomit)
Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Calcinosis (calcium deposits in any soft tissue)

40-49:

Blood cholesterol increased
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Coordination abnormal (abnormal movement)
Drug addiction
Drug dependence
Drug effect decreased
Drug hypersensitivity
Drug ineffective

50-59:

Anger
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Personality change
Pneumonia
Abnormal behaviour
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Completed suicide (act of taking one's own life)
Death
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Fall

60+:

Arthralgia (joint pain)
Bedridden
Blood pressure increased
Chills (felling of cold)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Decreased appetite
Dysgeusia (disorder of the sense of taste)
Dysstasia (difficulty in standing)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypoaesthesia facial (reduced sense of touch or sensation on face)

What are the existing conditions these people have? *

High Blood Cholesterol: 15 people, 25.00%
Chest Pain: 15 people, 25.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 15 people, 25.00%
Migraine (headache): 15 people, 25.00%
Cardiac Disorder: 14 people, 23.33%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 14 people, 23.33%
Diabetes: 14 people, 23.33%
Insomnia (sleeplessness): 14 people, 23.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 21.67%
Depression: 12 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Methocarbamol and Tylenol w/ codeine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously