Methotrexate sodium and Inh drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate sodium (methotrexate sodium) and Inh (isoniazid). Common drug interactions include drug resistance among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate sodium and Inh. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,680 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

What is Inh?

Inh has active ingredients of isoniazid. It is often used in latent tuberculosis. eHealthMe is studying from 646 Inh users. Check the latest studies of Inh.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

17 people who take Methotrexate sodium and Inh together, and have interactions are studied.

Methotrexate sodium and Inh drug interactions.

What are the common drug interactions of Methotrexate Sodium and Inh, by gender? *:

female:

Drug resistance (reduction in effectiveness of a drug)
Adverse event
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fatigue (feeling of tiredness)
Fibula fracture
Localised infection (infection at the single location)
Oesophageal stenosis (narrowing of oesophagus)
Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
Tibia fracture (fracture of lower leg bone)
Wound

male:

Arthralgia (joint pain)
Drug ineffective
Fatigue (feeling of tiredness)
Joint swelling
Mycobacterium tuberculosis complex test positive
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Weight decreased
Chest pain
Eye pain
Ocular hyperaemia (an abnormally large amount of blood in eye)

What are the common drug interactions of Methotrexate Sodium and Inh, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug resistance (reduction in effectiveness of a drug)

10-19:

n/a

20-29:

n/a

30-39:

Lung disorder (lung disease)

40-49:

n/a

50-59:

Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Chest pain
Drug hypersensitivity
Eye pain
Ocular hyperaemia (an abnormally large amount of blood in eye)

60+:

Fatigue (feeling of tiredness)
Adverse event
Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
Tibia fracture (fracture of lower leg bone)
Weight decreased
Wound
Aphonia (inability to produce voice)
Cough
Dyspepsia (indigestion)
Hypoaesthesia (reduced sense of touch or sensation)

What are the existing conditions these people have? *

Pain: 4 people, 23.53%
Osteoporosis (bones weak and more likely to break): 2 people, 11.76%
Neuropathy Peripheral (surface nerve damage): 2 people, 11.76%
Inflammation: 2 people, 11.76%
High Blood Pressure: 2 people, 11.76%
Gynecomastia (enlargement of the gland tissue of the male breast): 2 people, 11.76%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 2 people, 11.76%
Chest Pain: 2 people, 11.76%
Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 1 person, 5.88%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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