Methotrexate sodium and Nuvaring drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate sodium (methotrexate sodium) and Nuvaring (ethinyl estradiol; etonogestrel). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate sodium and Nuvaring. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

What is Nuvaring?

Nuvaring has active ingredients of ethinyl estradiol; etonogestrel. It is often used in birth control. eHealthMe is studying from 28,730 Nuvaring users. Check the latest studies of Nuvaring.

On Jul, 27, 2026

20 people who take Methotrexate sodium and Nuvaring together, and have interactions are studied.

Methotrexate sodium and Nuvaring drug interactions.

What are the common drug interactions of Methotrexate Sodium and Nuvaring, by gender? *:

female:

Fatigue (feeling of tiredness)
Abdominal pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Tremor (trembling or shaking movements in one or more parts of your body)
Viral infection
Arthralgia (joint pain)
Pain in extremity
Heart rate decreased
Hypotension (abnormally low blood pressure)
Infusion related reaction

male:

n/a

What are the common drug interactions of Methotrexate Sodium and Nuvaring, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Somnolence (a state of near-sleep, a strong desire for sleep)
Throat irritation
Weight decreased
Weight increased
Arthralgia (joint pain)
Blood pressure diastolic decreased
Body temperature increased
Dizziness
Drug ineffective

20-29:

Fatigue (feeling of tiredness)
Pyrexia (fever)
Arthralgia (joint pain)
Erythema (redness of the skin)
Headache (pain in head)
Abdominal pain
Anaemia (lack of blood)
Arthropathy
Back pain
Blood pressure diastolic increased

30-39:

Oropharyngeal pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Tremor (trembling or shaking movements in one or more parts of your body)
Viral infection
Influenza
Hot flush (sudden feelings of heat)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Frequent bowel movements
Abdominal distension
Abdominal pain

40-49:

Malaise (a feeling of general discomfort or uneasiness)
Sinusitis (inflammation of sinus)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 10 people, 50.00%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 5 people, 25.00%
Pain: 4 people, 20.00%
Anaemia (lack of blood): 3 people, 15.00%
Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 1 person, 5.00%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.00%
Joint Pain: 1 person, 5.00%
Fasciitis (infection of muscle surrounding tissue): 1 person, 5.00%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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