Methyldopa and Isosorbide dinitrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methyldopa (methyldopa) and Isosorbide dinitrate (isosorbide dinitrate). Common drug interactions include oligohydramnios among females and cardiac failure among males.

The phase IV clinical study analyzes what interactions people have when they take Methyldopa and Isosorbide dinitrate. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Methyldopa?

Methyldopa has active ingredients of methyldopa. It is often used in high blood pressure. eHealthMe is studying from 6,475 Methyldopa users. Check the latest studies of Methyldopa.

What is Isosorbide dinitrate?

Isosorbide dinitrate has active ingredients of isosorbide dinitrate. It is often used in angina. eHealthMe is studying from 13,180 Isosorbide dinitrate users. Check the latest studies of Isosorbide dinitrate.

On Jul, 03, 2026

19 people who take Methyldopa and Isosorbide dinitrate together, and have interactions are studied.

Methyldopa and Isosorbide dinitrate drug interactions.

What are the common drug interactions of Methyldopa and Isosorbide Dinitrate, by gender? *:

female:

Oligohydramnios (a condition in pregnancy characterized by a deficiency of amniotic fluid)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
Maternal exposure during pregnancy (use of substance during pregnancy)
Peripartum cardiomyopathy (deterioration in cardiac function presenting typically between the last month of pregnancy and up to five months postpartum)
Death
Ascites (accumulation of fluid in the abdominal cavity)
Biliary dilatation
Cardiomegaly (increased size of heart than normal)
Electrocardiogram pq interval prolonged

male:

Cardiac failure
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Compression fracture (fracture due to pressure caused by injury)
Decreased appetite
Drug hypersensitivity
Dry mouth
Dysgeusia (disorder of the sense of taste)
Eructation (release of gas from the digestive tract)
Fall
Frequent bowel movements

What are the common drug interactions of Methyldopa and Isosorbide Dinitrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Oligohydramnios (a condition in pregnancy characterized by a deficiency of amniotic fluid)
Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
Maternal exposure during pregnancy (use of substance during pregnancy)
Peripartum cardiomyopathy (deterioration in cardiac function presenting typically between the last month of pregnancy and up to five months postpartum)
Live birth
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)

30-39:

n/a

40-49:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Ageusia (loss of taste functions of the tongue)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Compression fracture (fracture due to pressure caused by injury)
Decreased appetite
Dry mouth
Dysgeusia (disorder of the sense of taste)
Eructation (release of gas from the digestive tract)

50-59:

Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)

60+:

Cardiac failure
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Fluid overload (too much fluid in the blood)
Hallucination (an experience involving the perception of something not present)
Hepatic atrophy (liver is decreased in size)
Linear iga disease (a rare, idiopathic or drug-induced autoimmune blistering disease of skin)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Malaise (a feeling of general discomfort or uneasiness)
Mucosal ulceration (ulcers of mucous membrane)
Neurodermatitis (a skin disorder characterized by long lasting itching and scratching)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 21.05%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 15.79%
High Blood Cholesterol: 3 people, 15.79%
Type 2 Diabetes: 2 people, 10.53%
Cardiac Failure Congestive: 2 people, 10.53%
Constipation: 2 people, 10.53%
Delirium (wild excitement): 2 people, 10.53%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 10.53%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 2 people, 10.53%
Insomnia (sleeplessness): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

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