Methylene blue and Cefazolin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylene blue (methylene blue) and Cefazolin (cefazolin sodium). Common drug interactions include circulatory collapse among females and serotonin syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Methylene blue and Cefazolin. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Methylene blue?

Methylene blue has active ingredients of methylene blue. eHealthMe is studying from 1,061 Methylene blue users. Check the latest studies of Methylene blue.

What is Cefazolin?

Cefazolin has active ingredients of cefazolin sodium. It is often used in infection. eHealthMe is studying from 15,157 Cefazolin users. Check the latest studies of Cefazolin.

On Jul, 12, 2026

33 people who take Methylene blue and Cefazolin together, and have interactions are studied.

Methylene blue and Cefazolin drug interactions.

What are the common drug interactions of Methylene Blue and Cefazolin, by gender? *:

female:

Circulatory collapse
Pulseless electrical activity
Anaphylactic reaction (serious allergic reaction)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Drug effect decreased
Hypotension (abnormally low blood pressure)

male:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Trismus (reduced opening of the jaws)
Burkholderia test positive
Syncope (loss of consciousness with an inability to maintain postural tone)
Agitation (state of anxiety or nervous excitement)
Confusional state
Hypertension (high blood pressure)
Restlessness (not able to rest)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the common drug interactions of Methylene Blue and Cefazolin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Blood creatinine increased
Pseudomonal sepsis (pseudomonas infections are diseases caused by a bacterium from the genus pseudomonas)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
White blood cell count increased
Hyperreflexia (overactive or over responsive reflexes)
Muscle rigidity (muscle stiffness)
Nystagmus (a condition of involuntary eye movement)

30-39:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Anaphylactic reaction (serious allergic reaction)

40-49:

Drug effect decreased
Drug ineffective
Hypotension (abnormally low blood pressure)
Circulatory collapse
Pulseless electrical activity
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)

50-59:

Burkholderia test positive
Respiratory disorder (respiratory disease)
Sputum culture positive
Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Hyperkalaemia (damage to or disease of the kidney)
Immunosuppressant drug level increased

What are the existing conditions these people have? *

Depression: 19 people, 57.58%
Pain: 18 people, 54.55%
General Anaesthesia: 7 people, 21.21%
Neuromuscular Blockade Reversal: 6 people, 18.18%
Anaesthesia: 5 people, 15.15%
Sedation: 3 people, 9.09%
Hypotonia (low muscle tone): 3 people, 9.09%
Appendicitis (inflammation of the appendix): 3 people, 9.09%
Vasoplegia Syndrome (low systemic vascular resistance): 2 people, 6.06%
Neuromuscular Blockade: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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