Methylfolate and Oxycodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylfolate (folic acid) and Oxycodone (oxycodone hydrochloride). Common drug interactions include anxiety among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Methylfolate and Oxycodone. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Methylfolate?

Methylfolate has active ingredients of folic acid. eHealthMe is studying from 1,018 Methylfolate users. Check the latest studies of Methylfolate.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

On Jul, 14, 2026

31 people who take Methylfolate and Oxycodone together, and have interactions are studied.

Methylfolate and Oxycodone drug interactions.

What are the common drug interactions of Methylfolate and Oxycodone, by gender? *:

female:

Anxiety
Depression
Fungal infection
Vomiting
Eye disorder
Fall
Fear
Hyperhidrosis (abnormally increased sweating)
Insomnia (sleeplessness)
Lumbar vertebral fracture

male:

Fatigue (feeling of tiredness)
Pyrexia (fever)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Quality of life decreased
Respiratory disorder (respiratory disease)
Wound
Diarrhoea
Drug ineffective
Hypoaesthesia (reduced sense of touch or sensation)

What are the common drug interactions of Methylfolate and Oxycodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Road traffic accident
Diarrhoea
Dyspepsia (indigestion)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Vomiting

40-49:

Alanine aminotransferase increased
Arthralgia (joint pain)
Aspartate aminotransferase increased
Cardiac disorder
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Cerebral artery embolism (sudden blocking of an artery by a clot or foreign material)
Cerebral cyst (fluid filled tumour of brain)
Depression
Epstein-barr virus infection
Headache (pain in head)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Eye disorder
Fall
Fear
Lumbar vertebral fracture
Memory impairment
Post procedural haemorrhage (post procedural bleeding)
Spinal compression fracture (fracture due to spinal compression on bone)

60+:

Anxiety
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Malaise (a feeling of general discomfort or uneasiness)
Oxygen saturation decreased
Pyrexia (fever)
Sputum increased
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary tract infection
Vitamin b6 deficiency
Hyperhidrosis (abnormally increased sweating)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 32.26%
Migraine (headache): 7 people, 22.58%
Depression: 7 people, 22.58%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 16.13%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.90%
Neuralgia (pain in one or more nerves): 4 people, 12.90%
Hiv Infection: 4 people, 12.90%
Stress And Anxiety: 3 people, 9.68%
Combined Immunodeficiency: 3 people, 9.68%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 3 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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