Methylfolate and Plavix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylfolate (folic acid) and Plavix (clopidogrel bisulfate). Common drug interactions include fatigue among females and rash among males.

The phase IV clinical study analyzes what interactions people have when they take Methylfolate and Plavix. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Methylfolate?

Methylfolate has active ingredients of folic acid. eHealthMe is studying from 1,018 Methylfolate users. Check the latest studies of Methylfolate.

What is Plavix?

Plavix has active ingredients of clopidogrel bisulfate. It is often used in stent. eHealthMe is studying from 151,178 Plavix users. Check the latest studies of Plavix.



On Jul, 11, 2026

19 people who take Methylfolate and Plavix together, and have interactions are studied.

Methylfolate and Plavix drug interactions.

What are the common drug interactions of Methylfolate and Plavix, by gender? *:

female:

  1. Fatigue (feeling of tiredness)
  2. Headache (pain in head)
  3. Depression
  4. Muscular weakness (muscle weakness)
  5. Asthenia (weakness)
  6. Cellulitis (infection under the skin)
  7. Contusion (a type of hematoma of tissue in which capillaries)
  8. Cough
  9. Dehydration (dryness resulting from the removal of water)
  10. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

male:

  1. Rash
  2. Anaemia (lack of blood)
  3. Neuropathy peripheral (surface nerve damage)
  4. Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
  5. Polyp
  6. Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
  7. Aura
  8. Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
  9. Cerebral infarction (less blood supply to brain resulting tissue damage)
  10. Cluster headache (one-sided head pain with tearing)

What are the common drug interactions of Methylfolate and Plavix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Cardiac disorder
  2. Cellulitis (infection under the skin)
  3. Dehydration (dryness resulting from the removal of water)
  4. Depression
  5. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  6. Fatigue (feeling of tiredness)
  7. Headache (pain in head)
  8. Insomnia (sleeplessness)
  9. Lupus nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue)
  10. Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)

30-39:

n/a

40-49:

n/a

50-59:

  1. Appendicitis (inflammation of the appendix)
  2. Bacterial infection

60+:

  1. Fatigue (feeling of tiredness)
  2. Asthenia (weakness)
  3. Anaemia (lack of blood)
  4. Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
  5. Chronic kidney disease
  6. Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
  7. Renal failure (kidney dysfunction)
  8. Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
  9. Abdominal discomfort
  10. Abdominal distension

What are the existing conditions these people have? *

  1. High Blood Cholesterol: 6 people, 31.58%
  2. High Blood Pressure: 6 people, 31.58%
  3. Stress And Anxiety: 4 people, 21.05%
  4. Depression: 4 people, 21.05%
  5. Muscle Spasms (muscle contraction): 4 people, 21.05%
  6. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 21.05%
  7. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 15.79%
  8. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 15.79%
  9. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.53%
  10. Amyloidosis (a tumour within which amyloid is produced): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Methylfolate and Plavix?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Methylfolate and Plavix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylfolate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Plavix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methylfolate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Plavix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on folic acid and clopidogrel bisulfate (the active ingredients of Methylfolate and Plavix, respectively), and Methylfolate and Plavix (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: