Methylfolate and Restasis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylfolate (folic acid) and Restasis (cyclosporine). Common drug interactions include migraine among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Methylfolate and Restasis. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Methylfolate?

Methylfolate has active ingredients of folic acid. eHealthMe is studying from 1,018 Methylfolate users. Check the latest studies of Methylfolate.

What is Restasis?

Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.

On Jul, 18, 2026

34 people who take Methylfolate and Restasis together, and have interactions are studied.

Methylfolate and Restasis drug interactions.

What are the common drug interactions of Methylfolate and Restasis, by gender? *:

female:

Migraine (headache)
Sinusitis (inflammation of sinus)
Insomnia (sleeplessness)
Oral fungal infection
Oedema (fluid collection in tissue)
Accident at home
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Fall
Fatigue (feeling of tiredness)
Foot fracture

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cardiac procedure complication
Malaise (a feeling of general discomfort or uneasiness)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Spinal fracture (fracture in one of vertebrae)
Thoracic vertebral fracture
Bone density decreased
Depression
Emotional distress

What are the common drug interactions of Methylfolate and Restasis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Sinusitis (inflammation of sinus)
Accident at home
Infusion related reaction
Limb injury
Migraine (headache)
Nephrolithiasis (calculi in the kidneys)
Oral fungal infection
Osteochondrosis (a family of orthopaedic diseases of the joint that occur in children and adolescents)
Pyrexia (fever)
Rash pruritic (redness with itching)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 29.41%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 26.47%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 20.59%
Migraine (headache): 6 people, 17.65%
Primary Immunodeficiency Syndrome: 3 people, 8.82%
Migraine Without Aura (headache without neurological problems): 3 people, 8.82%
Immunodeficiency: 3 people, 8.82%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.88%
Gastric Ulcer (stomach ulcer): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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