Methylphenidate and Eszopiclone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Eszopiclone (eszopiclone). Common drug interactions include muscular weakness among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Eszopiclone. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Eszopiclone?

Eszopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 4,258 Eszopiclone users. Check the latest studies of Eszopiclone.

On Jul, 30, 2026

21 people who take Methylphenidate and Eszopiclone together, and have interactions are studied.

Methylphenidate and Eszopiclone drug interactions.

What are the common drug interactions of Methylphenidate and Eszopiclone, by gender? *:

female:

Muscular weakness (muscle weakness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
Nasopharyngitis (inflammation of the nasopharynx)
Neck pain
Neuralgia (pain in one or more nerves)
Neurogenic bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion)
Night sweats (sweating in night)
Nocturia (the need to get up in the night to urinate)
Oedema (fluid collection in tissue)

male:

Abdominal discomfort
Abnormal dreams
Dizziness
Dyspnoea (difficult or laboured respiration)
Fall
Fatigue (feeling of tiredness)
Head injury
Loss of consciousness
Memory impairment
Muscle spasms (muscle contraction)

What are the common drug interactions of Methylphenidate and Eszopiclone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bladder discomfort
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Nephrocalcinosis (a condition in which calcium levels in the kidneys are increased)
Renal impairment (severely reduced kidney function)
Drug effect prolonged
Facial bones fracture (bone fracture of face)
Fall

40-49:

Road traffic accident
Sinusitis (inflammation of sinus)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Snoring
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress urinary incontinence (leak urine with things like coughing, sneezing or exercise)
Wheezing (a high-pitched whistling sound made while you breath)
Anxiety
Chest pain
Dyspnoea (difficult or laboured respiration)

50-59:

Drug ineffective
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Spinal stenosis (narrowing of spinal column)
Balance disorder
Blood calcium decreased
Blood chloride increased
Blood creatine increased
Blood glucose increased
Blood urea nitrogen/creatinine ratio decreased
Bradycardia (abnormally slow heart action)

60+:

Flatulence (flatus expelled through the anus)
Frequent bowel movements
Skin ulcer
Weight decreased
Initial insomnia (feeling of inadequate or poor-quality sleep)
Limb injury
Lower limb fracture
Muscular weakness (muscle weakness)
Nausea (feeling of having an urge to vomit)
Onychomycosis (fungal infection of the nail)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 61.90%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 57.14%
Drowsiness: 6 people, 28.57%
Stress And Anxiety: 2 people, 9.52%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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