Methylphenidate and Imodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Imodium (loperamide hydrochloride). Common drug interactions include headache among females and dyspepsia among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Imodium. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Imodium?

Imodium has active ingredients of loperamide hydrochloride. It is often used in diarrhea. eHealthMe is studying from 45,092 Imodium users. Check the latest studies of Imodium.

On Jul, 06, 2026

40 people who take Methylphenidate and Imodium together, and have interactions are studied.

Methylphenidate and Imodium drug interactions.

What are the common drug interactions of Methylphenidate and Imodium, by gender? *:

female:

Headache (pain in head)
Cholangitis (infection of the bile duct)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Neuralgia (pain in one or more nerves)
Cholestasis of pregnancy (normal flow of bile in the gallbladder is affected by the high amounts of pregnancy hormones)
Feeling jittery
Morning sickness (sickness in morning during pregnancy)
Premature labour
Hypertension (high blood pressure)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)

male:

Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Surgery
Weight increased
Blood cholesterol increased
Abdominal pain upper
Asthenia (weakness)
Blood pressure fluctuation
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Decreased appetite

What are the common drug interactions of Methylphenidate and Imodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Device failure
Drug ineffective
Lower respiratory tract infection
Malaise (a feeling of general discomfort or uneasiness)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

30-39:

Anxiety
Atrioventricular block first degree (heart block first degree)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Drug abuse
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyskinesia (abnormality or impairment of voluntary movement)
Electrocardiogram qt prolonged
Hyperventilation
Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Increased appetite
Lower limb fracture
Muscle spasms (muscle contraction)
Abdominal abscess (collection of pus in abdomen)
Abdominal discomfort
Blood cholesterol increased
Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Haematochezia (passage of stools containing blood)

50-59:

Cholangitis (infection of the bile duct)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Headache (pain in head)
Neuralgia (pain in one or more nerves)
Dyspepsia (indigestion)
Gastric perforation (hole in stomach)
Psoriasis (immune-mediated disease that affects the skin)

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Nerve compression
Pancreatic carcinoma (pancreatic cancer)
Pyrexia (fever)
Sinusitis (inflammation of sinus)
Asthenia (weakness)
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Liver disorder (liver diseases)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 45.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 27.50%
Insomnia (sleeplessness): 7 people, 17.50%
Uterine Contractions During Pregnancy: 4 people, 10.00%
Hypersensitivity: 4 people, 10.00%
Colitis (inflammation of colon): 3 people, 7.50%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.00%
Back Pain: 2 people, 5.00%
Calcium Deficiency (lack of calcium): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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