Methylphenidate and Zonisamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Zonisamide (zonisamide). Common drug interactions include somnolence among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Zonisamide. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Zonisamide?

Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 11,445 Zonisamide users. Check the latest studies of Zonisamide.

On Aug, 02, 2026

40 people who take Methylphenidate and Zonisamide together, and have interactions are studied.

Methylphenidate and Zonisamide drug interactions.

What are the common drug interactions of Methylphenidate and Zonisamide, by gender? *:

female:

Somnolence (a state of near-sleep, a strong desire for sleep)
Fall
Ankle fracture
Cardiac disorder
Lung disorder (lung disease)
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Blood pressure increased
Chills (felling of cold)
Depression

male:

Fall
Pain
Depressed mood
Enuresis (repeated inability to control urination)
Hypertension (high blood pressure)
Vomiting
Psychomotor hyperactivity (feelings of extreme restlessness)
Suicidal ideation
Hallucination, auditory (perceiving sounds without auditory stimulus)
Persecutory delusion

What are the common drug interactions of Methylphenidate and Zonisamide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Ataxia (loss of full control of bodily movements)
Decreased appetite
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fatigue (feeling of tiredness)
Muscle twitching
Salivary hypersecretion (excess saliva secretion)
Sedation
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight decreased

20-29:

Hallucination, auditory (perceiving sounds without auditory stimulus)
Persecutory delusion
Psychotic disorder

30-39:

Fall
Pain
Abnormal sleep-related event
Blood pressure increased
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Constipation
Defaecation urgency (a sudden compelling urge to defecate)
Gastrointestinal hypermotility (over activity of the intestinal tract)
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Headache (pain in head)

40-49:

Drug hypersensitivity
Dry mouth
Electrocardiogram qt prolonged

50-59:

Suicide attempt

60+:

Ankle fracture
Cardiac disorder
Gait disturbance
Influenza like illness
Memory impairment
Muscular weakness (muscle weakness)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)
Stomatitis (inflammation of mucous membrane of mouth)
Tremor (trembling or shaking movements in one or more parts of your body)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 55.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 16 people, 40.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 17.50%
Gait Disturbance: 4 people, 10.00%
Drowsiness: 4 people, 10.00%
Partial Seizures (seizures which affect only a part of the brain at onset): 3 people, 7.50%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 5.00%
Depression: 2 people, 5.00%
Birth Control: 2 people, 5.00%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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