Methylprednisolone and Exjade drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Methylprednisolone (methylprednisolone) and Exjade (deferasirox). Common drug interactions include anuria among females and platelet count decreased among males.
The phase IV clinical study analyzes what interactions people have when they take Methylprednisolone and Exjade. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.
What is Methylprednisolone?
Methylprednisolone has active ingredients of methylprednisolone. It is often used in inflammation. eHealthMe is studying from 59,645 Methylprednisolone users. Check the latest studies of Methylprednisolone.
What is Exjade?
Exjade has active ingredients of deferasirox. It is often used in iron overload. eHealthMe is studying from 29,456 Exjade users. Check the latest studies of Exjade.
26 people who take Methylprednisolone and Exjade together, and have interactions are studied.

What are the common drug interactions of Methylprednisolone and Exjade, by gender? *:
female:
- Anuria (failure of the kidneys to produce urine)
- Arteriosclerosis (thickening and hardening of arteries)
- Ascites (accumulation of fluid in the abdominal cavity)
- Blood pressure increased
- Bone marrow disorder
- Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
- C-reactive protein increased
- Cachexia (loss of weight)
- Cerebral haemorrhage (bleeding within the brain)
- Confusional state
male:
- Platelet count decreased
- Pneumonia
- Respiratory disorder (respiratory disease)
- Transplant rejection (a transplant material is not worked)
- Wheezing (a high-pitched whistling sound made while you breath)
- Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
- Rash
- Alanine aminotransferase increased
- Anaemia (lack of blood)
- Aspartate aminotransferase increased
What are the common drug interactions of Methylprednisolone and Exjade, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
- Pyrexia (fever)
- Acute chest syndrome (acute chest pain, fever and difficulty breathing)
- Asthma
- Cough
- Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
- Otitis media (inflammation of the middle ear)
- Pneumonia
- Respiratory disorder (respiratory disease)
- Wheezing (a high-pitched whistling sound made while you breath)
- Abdominal distension
10-19:
- Bk virus infection
- Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
- Microangiopathy (disease of the capillaries (very small blood vessels), in which the capillary walls become so thick and weak that they bleed, leak protein)
- Vomiting
- Asthenia (weakness)
- Calcium deficiency (lack of calcium)
- Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
- Infection
- Blood albumin decreased
- Blood calcium decreased
20-29:
- Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
- Rash
30-39:
- General physical health deterioration (weak health status)
- Hepatic steatosis (fatty liver disease)
- Hepatitis (inflammation of the liver)
- Hip fracture
- Hyperlipidaemia (presence of excess lipids in the blood)
- Hyperthermia (body temperature greatly above normal)
- Hypertriglyceridaemia (excess of triglycerides in the blood)
- Hypoaesthesia (reduced sense of touch or sensation)
- Hypokalaemia (low potassium)
- Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
40-49:
- Transplant rejection (a transplant material is not worked)
- Anaemia (lack of blood)
- Haemoglobin decreased
- Leukopenia (less number of white blood cells in blood)
- Platelet count decreased
- White blood cell count decreased
50-59:
- Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
- Asthenia (weakness)
- Chest discomfort
- Chest pain
- Confusional state
- Diarrhoea
- Dizziness
- Dyspepsia (indigestion)
- Dyspnoea (difficult or laboured respiration)
- Emotional distress
60+:
- Oedema peripheral (superficial swelling)
- Thrombocytopenia (decrease of platelets in blood)
- Fatigue (feeling of tiredness)
- Headache (pain in head)
- Hemiplegia (paralysis of one side of the body)
- Hemisensory neglect (loss of sensation on one side of the body-neglect)
- Memory impairment
- Somnolence (a state of near-sleep, a strong desire for sleep)
- Visual impairment
- Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
What are the existing conditions these people have? *
- Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 8 people, 30.77%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 19.23%
- Serum Ferritin Increased: 4 people, 15.38%
- High Blood Pressure: 4 people, 15.38%
- Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 4 people, 15.38%
- Anaemia (lack of blood): 4 people, 15.38%
- Aplastic Anemia: 3 people, 11.54%
* Approximation only. Some reports may have incomplete information.
Do you take Methylprednisolone and Exjade?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Methylprednisolone (59,645 reports)
- Exjade (29,456 reports)
Browse all drug interactions of Methylprednisolone and Exjade:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Methylprednisolone:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Exjade:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Methylprednisolone and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Exjade and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Díaz-García JD, Gallegos-Villalobos A, Gonzalez-Espinoza L, Sanchez-Ni?o MD, Villarrubia J, Ortiz A, "Deferasirox nephrotoxicity [mdash] the knowns and unknowns", Nature reviews nephrology, 2014 Oct .
- Riva A, "Comment on: A record number of fatalities in many categories of patients treated with deferasirox: loopholes in regulatory and marketing procedures undermine patient safety and misguide public funds?", Expert opinion on drug safety, 2013 Sep .
- Riva A, "Deferasirox's toxicity", The Lancet, 2013 Jul .
- Kontoghiorghes GJ, "Turning a blind eye to deferasirox's toxicity?", The Lancet, 2013 Apr .
- Kontoghiorghes GJ, "A record number of fatalities in many categories of patients treated with deferasirox: loopholes in regulatory and marketing procedures undermine patient safety and misguide public funds?", Taylor & Francis, 2013 Jan .
- Díaz-García JD, Gallegos-Villalobos A, Gonzalez-Espinoza L, Sanchez-Ni?o MD, Villarrubia J, Ortiz A, "Deferasirox nephrotoxicity [mdash] the knowns and unknowns", Nature reviews nephrology, 2014 Oct .
- Riva A, "Comment on: A record number of fatalities in many categories of patients treated with deferasirox: loopholes in regulatory and marketing procedures undermine patient safety and misguide public funds?", Expert opinion on drug safety, 2013 Sep .
- Riva A, "Deferasirox's toxicity", The Lancet, 2013 Jul .
- Kontoghiorghes GJ, "Turning a blind eye to deferasirox's toxicity?", The Lancet, 2013 Apr .
- Kontoghiorghes GJ, "A record number of fatalities in many categories of patients treated with deferasirox: loopholes in regulatory and marketing procedures undermine patient safety and misguide public funds?", Taylor & Francis, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on methylprednisolone and deferasirox (the active ingredients of Methylprednisolone and Exjade, respectively), and Methylprednisolone and Exjade (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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