Metrogel and Norco drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metrogel (metronidazole) and Norco (acetaminophen; hydrocodone bitartrate). Common drug interactions include hypoglycaemia among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Metrogel and Norco. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Metrogel?

Metrogel has active ingredients of metronidazole. It is often used in rosacea. eHealthMe is studying from 2,819 Metrogel users. Check the latest studies of Metrogel.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

On Aug, 09, 2026

63 people who take Metrogel and Norco together, and have interactions are studied.

What are the common drug interactions of Metrogel and Norco, by gender? *:

female:

Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypoproteinaemia (too little prolactin circulating in the blood)
Hypotension (abnormally low blood pressure)
Injury
Insomnia (sleeplessness)
Lacrimation increased
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Neck pain
Neoplasm progression (growth of tumour)

male:

Cough
Pyrexia (fever)
Asthenia (weakness)
Blood urine present
Diabetic ulcer
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Infection
Nephrolithiasis (calculi in the kidneys)

What are the common drug interactions of Metrogel and Norco, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac disorder
Migraine (headache)
Thrombosis (formation of a blood clot inside a blood vessel)
Type 1 diabetes mellitus
Cardiac failure congestive
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Joint injury
Viral cardiomyopathy (weakness in the muscle of the heart due to viral infection)

30-39:

Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Bronchitis acute (acute inflammation of the mucous membrane in the bronchial tubes)
Cachexia (loss of weight)
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Difficulty in walking
Gastritis (inflammation of stomach)
Iron deficiency anaemia
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Lethargy (tiredness)

40-49:

Anaphylactic reaction (serious allergic reaction)
Arthralgia (joint pain)
Chronic kidney disease
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hot flush (sudden feelings of heat)
Renal failure (kidney dysfunction)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)

50-59:

Dysuria (painful or difficult urination)
Exostosis (formation of new bone on the surface of a bone)
Foot deformity (functional disability of foot)
Headache (pain in head)
Hot flush (sudden feelings of heat)
Infection
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Muscular weakness (muscle weakness)
Oropharyngeal pain
Pancreatitis acute (sudden inflammation of pancreas)

60+:

Asthenia (weakness)
Alopecia (absence of hair from areas of the body)
Alanine aminotransferase increased
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthralgia (joint pain)
Aspartate aminotransferase increased
Ataxia (loss of full control of bodily movements)
Blood copper decreased
Blood culture positive

What are the existing conditions these people have? *

Stress And Anxiety: 10 people, 15.87%
Depression: 9 people, 14.29%
High Blood Pressure: 8 people, 12.70%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 12.70%
High Blood Cholesterol: 8 people, 12.70%
Nausea (feeling of having an urge to vomit): 5 people, 7.94%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 7.94%
Inflammation: 5 people, 7.94%
Sleep Disorder: 5 people, 7.94%
Diabetes: 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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