Metrogel and Oxycodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metrogel (metronidazole) and Oxycodone (oxycodone hydrochloride). Common drug interactions include acne among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Metrogel and Oxycodone. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Metrogel?

Metrogel has active ingredients of metronidazole. It is often used in rosacea. eHealthMe is studying from 2,819 Metrogel users. Check the latest studies of Metrogel.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

78 people who take Metrogel and Oxycodone together, and have interactions are studied.

Metrogel and Oxycodone drug interactions.

What are the common drug interactions of Metrogel and Oxycodone, by gender? *:

female:

Acne (skin problems that cause pimples)
Blood pressure systolic increased
Foot deformity (functional disability of foot)
Heart rate decreased
Ill-defined disorder
Infusion related reaction
Insomnia (sleeplessness)
Joint swelling
Oedema peripheral (superficial swelling)
Oxygen saturation decreased

male:

Decreased appetite
Asthenia (weakness)
Disease progression
Dyspnoea (difficult or laboured respiration)
Fall
Fatigue (feeling of tiredness)
Muscular weakness (muscle weakness)
Skin ulcer
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the common drug interactions of Metrogel and Oxycodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Asthenia (weakness)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Disease progression
Hypoxia (low oxygen in tissues)
Malignant neoplasm progression (cancer tumour came back)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Pulmonary embolism (blockage of the main artery of the lung)

20-29:

Persistent foetal circulation (baby's blood does not need to pass by the lungs)
Menstruation irregular
Pelvic pain
Thrombosis (formation of a blood clot inside a blood vessel)

30-39:

Anxiety
Renal failure (kidney dysfunction)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Chronic kidney disease
Emotional distress
Fibromyalgia (a long-term condition which causes pain all over the body)
General physical health deterioration (weak health status)
Haemorrhage (bleeding)
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

40-49:

Weight decreased
Lymphadenopathy (disease or enlargement of lymph nodes)
Arthralgia (joint pain)
Chest wall pain
Fatigue (feeling of tiredness)
Herpes simplex (herpes simplex is a common viral infection)
Herpes zoster
Immunodeficiency
Lymphocytosis (an increase in the number or proportion of lymphocytes in the blood)
Pancreatitis (inflammation of pancreas)

50-59:

Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Nerve compression
Pruritus (severe itching of the skin)
Respiratory disorder (respiratory disease)
Sinusitis (inflammation of sinus)
Skin disorder (skin disease)
Urinary tract infection
Weight increased
Diarrhoea

60+:

Diarrhoea
Asthenia (weakness)
Night sweats (sweating in night)
Urinary tract infection
Abdominal discomfort
Abdominal pain
Abdominal pain lower
Acne (skin problems that cause pimples)
Blood glucose increased
Body temperature decreased

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 22 people, 28.21%
Emotional Disorder: 18 people, 23.08%
Urinary Tract Infection: 15 people, 19.23%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 16.67%
High Blood Cholesterol: 12 people, 15.38%
Depression: 9 people, 11.54%
High Blood Pressure: 9 people, 11.54%
Infection: 8 people, 10.26%
Stress And Anxiety: 8 people, 10.26%
Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins): 7 people, 8.97%

* Approximation only. Some reports may have incomplete information.

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