Metrogel and Restasis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metrogel (metronidazole) and Restasis (cyclosporine). Common drug interactions include nasopharyngitis among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Metrogel and Restasis. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Metrogel?

Metrogel has active ingredients of metronidazole. It is often used in rosacea. eHealthMe is studying from 2,819 Metrogel users. Check the latest studies of Metrogel.

What is Restasis?

Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

98 people who take Metrogel and Restasis together, and have interactions are studied.

Metrogel and Restasis drug interactions.

What are the common drug interactions of Metrogel and Restasis, by gender? *:

female:

Nasopharyngitis (inflammation of the nasopharynx)
Neck pain
Nephrolithiasis (calculi in the kidneys)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Strabismus (a disorder in which the two eyes do not line up in the same direction)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Tendonitis (a condition that causes pain and swelling of tendons)
Therapeutic response unexpected
Oropharyngeal pain
Reaction to food additive

male:

Decreased appetite
Dehydration (dryness resulting from the removal of water)
Fall
Femur fracture
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hepatitis (inflammation of the liver)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Metrogel and Restasis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Heart rate decreased
Hypotension (abnormally low blood pressure)
Palpitations (feelings or sensations that your heart is pounding or racing)
Precancerous skin lesion
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Surgery

40-49:

Injection site pain
Abdominal abscess (collection of pus in abdomen)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Vomiting

50-59:

Asthenia (weakness)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Back pain
Bipolar disorder (mood disorder)
Blood cholesterol increased
Blood potassium decreased
Blood pressure decreased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cataract (clouding of the lens inside the eye)
Communication disorder (speech and language disorder)

60+:

Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Memory impairment
Mood swings (an extreme or rapid change in mood)
Muscle spasms (muscle contraction)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Nasal discomfort
Nausea (feeling of having an urge to vomit)
Neck injury
Nervousness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 30 people, 30.61%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 27 people, 27.55%
Drowsiness: 11 people, 11.22%
Pain: 9 people, 9.18%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 8.16%
High Blood Cholesterol: 8 people, 8.16%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 7.14%
Stress And Anxiety: 6 people, 6.12%
Psoriasis (immune-mediated disease that affects the skin): 6 people, 6.12%
High Blood Pressure: 6 people, 6.12%

* Approximation only. Some reports may have incomplete information.

Do you take Metrogel and Restasis?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously