Metrogel and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metrogel (metronidazole) and Sinemet (carbidopa; levodopa). Common drug interactions include bedridden among females and renal failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Metrogel and Sinemet. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Metrogel?

Metrogel has active ingredients of metronidazole. It is often used in rosacea. eHealthMe is studying from 2,819 Metrogel users. Check the latest studies of Metrogel.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

On Jul, 26, 2026

14 people who take Metrogel and Sinemet together, and have interactions are studied.

What are the common drug interactions of Metrogel and Sinemet, by gender? *:

female:

Bedridden
Compulsive shopping
Emotional distress
Headache (pain in head)
Hypersexuality
Libido increased (increased sexual urge to have sex)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pathological gambling

male:

Renal failure acute (rapid kidney dysfunction)
Chorioretinopathy (collection of fluid under the retina that results in visual distortion)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Prostatic specific antigen increased
Renal cell carcinoma stage iv (stage iv renal cell cancer have cancer that has spread to other organs, such as the lungs, liver, bones, or brain, and may have spread to lymph nodes)
Renal failure (kidney dysfunction)
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Visual impairment
Vitreous floaters (spots before the eyes)

What are the common drug interactions of Metrogel and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Renal failure acute (rapid kidney dysfunction)
Disease progression
Renal cell carcinoma stage iv (stage iv renal cell cancer have cancer that has spread to other organs, such as the lungs, liver, bones, or brain, and may have spread to lymph nodes)
Renal failure (kidney dysfunction)

60+:

Chorioretinopathy (collection of fluid under the retina that results in visual distortion)
Bedridden
Prostatic specific antigen increased
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
Visual impairment
Vitreous floaters (spots before the eyes)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 4 people, 28.57%
Nausea And Vomiting: 4 people, 28.57%
Stress And Anxiety: 3 people, 21.43%
Drowsiness: 3 people, 21.43%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 14.29%
Blood Testosterone Decreased: 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Hyperkeratosis (thickening of the outer layer of the skin): 2 people, 14.29%
Hypersensitivity: 2 people, 14.29%
Muscle Spasms (muscle contraction): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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