Mevacor and Levothroid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mevacor (lovastatin) and Levothroid (levothyroxine sodium). Common drug interactions include basedow's disease among females and burning sensation among males.

The phase IV clinical study analyzes what interactions people have when they take Mevacor and Levothroid. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Mevacor?

Mevacor has active ingredients of lovastatin. It is often used in high blood cholesterol. eHealthMe is studying from 4,988 Mevacor users. Check the latest studies of Mevacor.

What is Levothroid?

Levothroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. eHealthMe is studying from 8,974 Levothroid users. Check the latest studies of Levothroid.



On Jul, 26, 2026

73 people who take Mevacor and Levothroid together, and have interactions are studied.

Mevacor and Levothroid drug interactions.

What are the common drug interactions of Mevacor and Levothroid, by gender? *:

female:

  1. Basedow's disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones)
  2. Bladder infection
  3. Blood sodium decreased
  4. Bone mass decreased
  5. Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
  6. Bundle branch block (disruption in the normal flow of electrical pulses that drive the heart beat)
  7. Chest pain
  8. Confusion
  9. Cor pulmonale (enlargement of the right ventricle of the heart)
  10. Cough

male:

  1. Burning sensation
  2. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  3. Alanine aminotransferase abnormal
  4. Aspartate aminotransferase abnormal
  5. Blindness
  6. Cardiac failure
  7. Cardiac failure congestive
  8. Cervical disc lesion (lesion between cervical vertebrae)
  9. Cervical spinal stenosis (narrowing of the spinal canal in the neck)
  10. Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Mevacor and Levothroid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Depressed mood
  2. Somnolence (a state of near-sleep, a strong desire for sleep)
  3. Therapeutic response unexpected

50-59:

  1. Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
  2. Osteoporosis (bones weak and more likely to break)
  3. Pain
  4. Plasma cell myeloma (cancer that begins in plasma cells)
  5. Visual impairment
  6. Hypoaesthesia (reduced sense of touch or sensation)
  7. Mania (a state of abnormally elevated or irritable mood)
  8. Papillary thyroid cancer
  9. Pernicious anaemia (anaemia due to lack of vitamin b12)
  10. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

60+:

  1. Anaemia (lack of blood)
  2. Neoplasm malignant (cancer tumour)
  3. Pain
  4. Plasma cell myeloma (cancer that begins in plasma cells)
  5. Visual impairment
  6. Hemiparesis (weakness on one side of the body)
  7. Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
  8. Platelet count decreased
  9. White blood cell count decreased
  10. Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

  1. Pain: 18 people, 24.66%
  2. Nausea (feeling of having an urge to vomit): 9 people, 12.33%
  3. Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 8 people, 10.96%
  4. Muscle Spasms (muscle contraction): 7 people, 9.59%
  5. Neuropathy Peripheral (surface nerve damage): 7 people, 9.59%
  6. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 9.59%
  7. Dyspnea (difficult or laboured breathing): 6 people, 8.22%
  8. Thalamic Infarction (tissue death of thalamus part of brain): 6 people, 8.22%
  9. Wheezing (a high-pitched whistling sound made while you breath): 6 people, 8.22%
  10. Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 5 people, 6.85%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Mevacor and Levothroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Mevacor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Levothroid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Mevacor and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Levothroid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on lovastatin and levothyroxine sodium (the active ingredients of Mevacor and Levothroid, respectively), and Mevacor and Levothroid (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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