Mexitil and Humalog drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mexitil (mexiletine hydrochloride) and Humalog (insulin lispro recombinant). Common drug interactions include femoral artery occlusion among females and drug rash with eosinophilia and systemic symptoms among males.

The phase IV clinical study analyzes what interactions people have when they take Mexitil and Humalog. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Mexitil?

Mexitil has active ingredients of mexiletine hydrochloride. eHealthMe is studying from 1,893 Mexitil users. Check the latest studies of Mexitil.

What is Humalog?

Humalog has active ingredients of insulin lispro recombinant. It is often used in diabetes. eHealthMe is studying from 137,127 Humalog users. Check the latest studies of Humalog.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

34 people who take Mexitil and Humalog together, and have interactions are studied.

What are the common drug interactions of Mexitil and Humalog, by gender? *:

female:

Femoral artery occlusion (obstruction in artery of femur)
Gastritis (inflammation of stomach)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Glycosylated haemoglobin increased
Graft infection (infection of graft site)
Graft thrombosis (clotting at graft)
Haematoma (collection of blood outside the blood vessels)
Hepatic steatosis (fatty liver disease)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hyperhidrosis (abnormally increased sweating)

male:

Drug rash with eosinophilia and systemic symptoms (adverse drug reactions with rash)
Pyrexia (fever)
Blood lactate dehydrogenase increased
C-reactive protein increased
Cytomegalovirus test positive
Erythema (redness of the skin)
Gamma-glutamyltransferase increased
Human herpes virus 6 serology positive
Oedema (fluid collection in tissue)
Pigmentation disorder (disturbances of human skin colour)

What are the common drug interactions of Mexitil and Humalog, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac valve disease (heart valve disease)
Cardiomyopathy (weakening of the heart muscle)
Cellulitis (infection under the skin)
Chest pain
Conduction disorder (serious disorder of the heart not responses proper to impulses)
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cough
Dehydration (dryness resulting from the removal of water)
Diarrhoea

50-59:

Blood lactic acid increased
Blood ph decreased
Glycosylated haemoglobin increased
Haematemesis (vomiting of blood)
Haemoglobin decreased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Diabetes mellitus inadequate control
Gastric ulcer haemorrhage (bleeding ulcer of stomach)

60+:

Pyrexia (fever)
Cough
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Multiple injuries
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Vitreous detachment (a condition of the eye in which the vitreous humour separates from the retina)
Vitreous haemorrhage (intraocular (inside the eye) bleeding)
Vomiting
Retinal tear

What are the existing conditions these people have? *

Arrhythmias (irregular heartbeat): 12 people, 35.29%
High Blood Pressure: 9 people, 26.47%
Type 2 Diabetes: 7 people, 20.59%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 6 people, 17.65%
Stable Angina (a constant chest pain): 5 people, 14.71%
Insomnia (sleeplessness): 5 people, 14.71%
Percutaneous Coronary Intervention: 3 people, 8.82%
Osteoporosis (bones weak and more likely to break): 3 people, 8.82%
Nerve Injury: 3 people, 8.82%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

Do you take Mexitil and Humalog?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously