Microzide and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Microzide (hydrochlorothiazide) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include fatigue among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Microzide and Bactrim. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Microzide?

Microzide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 994 Microzide users. Check the latest studies of Microzide.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

14 people who take Microzide and Bactrim together, and have interactions are studied.

Microzide and Bactrim drug interactions.

What are the common drug interactions of Microzide and Bactrim, by gender? *:

female:

Fatigue (feeling of tiredness)
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Arthropathy
Blood calcium decreased
Blood sodium decreased
Cellulitis (infection under the skin)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Palpitations (feelings or sensations that your heart is pounding or racing)
Visual impairment

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspnoea (difficult or laboured respiration)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Pneumonia viral
Pyrexia (fever)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Subcorneal pustular dermatosis (skin disease, especially one that is not accompanied by inflammation)
Emotional distress

What are the common drug interactions of Microzide and Bactrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Proteinuria (presence of protein in the urine)
Renal disorder (kidney disease)
Renal impairment (severely reduced kidney function)

50-59:

Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)
Cellulitis (infection under the skin)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Hypotension (abnormally low blood pressure)
Palpitations (feelings or sensations that your heart is pounding or racing)

60+:

Fatigue (feeling of tiredness)
Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Pyrexia (fever)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Subcorneal pustular dermatosis (skin disease, especially one that is not accompanied by inflammation)
Visual impairment
Arthropathy
Asthenia (weakness)
Blood calcium decreased
Blood sodium decreased

What are the existing conditions these people have? *

Pain: 7 people, 50.00%
Nausea (feeling of having an urge to vomit): 4 people, 28.57%
High Blood Cholesterol: 4 people, 28.57%
Multiple Myeloma (cancer of the plasma cells): 3 people, 21.43%
Stress And Anxiety: 3 people, 21.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 21.43%
Stable Angina (a constant chest pain): 2 people, 14.29%
Rickets (softening of bones): 2 people, 14.29%
Hiv Infection: 2 people, 14.29%
Hypersensitivity: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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