Midazolam and Cymbalta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Midazolam (midazolam) and Cymbalta (duloxetine hydrochloride). Common drug interactions include allodynia among females and drug intolerance among males.

The phase IV clinical study analyzes what interactions people have when they take Midazolam and Cymbalta. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Midazolam?

Midazolam has active ingredients of midazolam. eHealthMe is studying from 11,246 Midazolam users. Check the latest studies of Midazolam.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,974 Cymbalta users. Check the latest studies of Cymbalta.

On Aug, 06, 2026

47 people who take Midazolam and Cymbalta together, and have interactions are studied.

Midazolam and Cymbalta drug interactions.

What are the common drug interactions of Midazolam and Cymbalta, by gender? *:

female:

Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Bone density decreased
Cellulitis (infection under the skin)
Colitis ulcerative (inflammation of colon with ulcer)
Death
Fall
Gastric cancer stage iv (cancer cells have spread to distant organs)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematochezia (passage of stools containing blood)

male:

Drug intolerance (drug sensitivity)
Pancreatitis (inflammation of pancreas)
Anion gap increased
Asthenia (weakness)
Back disorder
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Catheter site pain
Constipation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Midazolam and Cymbalta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Hyperaesthesia

30-39:

Urinary tract infection
Viral upper respiratory tract infection
Weight decreased
Bone density decreased
Brain death
Cardiomegaly (increased size of heart than normal)
Colitis ulcerative (inflammation of colon with ulcer)
Haematochezia (passage of stools containing blood)
Hepatic failure (liver failure)
Nasopharyngitis (inflammation of the nasopharynx)

40-49:

Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess limb (limb infection)
Chronic kidney disease
Nerve injury
Pain
Perirectal abscess
Rectal abscess (pus in rectum)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Renal failure (kidney dysfunction)
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Iga nephropathy (kidney disease- condition prevents the kidneys from filtering waste)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)
Proteinuria (presence of protein in the urine)
Renal tubular necrosis (death of kidney tubules)

60+:

Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Prostate cancer
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Intervertebral disc degeneration (spinal disc degeneration)
Laryngeal cancer (cancer of the larynx)
Obesity (having too much body fat)
Osteochondrosis (a family of orthopaedic diseases of the joint that occur in children and adolescents)
Perineal abscess
Pituitary-dependent cushing's syndrome (pituitary dependent hypercortisolism)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 15 people, 31.91%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 15 people, 31.91%
Type 2 Diabetes: 12 people, 25.53%
Pain: 12 people, 25.53%
High Blood Pressure: 9 people, 19.15%
Diabetes: 9 people, 19.15%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 14.89%
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery): 7 people, 14.89%
Gastric Ulcer (stomach ulcer): 7 people, 14.89%
Diarrhea: 7 people, 14.89%

* Approximation only. Some reports may have incomplete information.

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