Midazolam and Micafungin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Midazolam (midazolam) and Micafungin (micafungin sodium). Common drug interactions include systemic inflammatory response syndrome among females and pneumonia among males.
The phase IV clinical study analyzes what interactions people have when they take Midazolam and Micafungin. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.
What is Midazolam?
Midazolam has active ingredients of midazolam. eHealthMe is studying from 11,246 Midazolam users. Check the latest studies of Midazolam.
What is Micafungin?
Micafungin has active ingredients of micafungin sodium. eHealthMe is studying from 6,562 Micafungin users. Check the latest studies of Micafungin.
97 people who take Midazolam and Micafungin together, and have interactions are studied.

What are the common drug interactions of Midazolam and Micafungin, by gender? *:
female:
- Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
- Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
- Cardiac tamponade (fluid accumulates in heart covering)
- Colitis (inflammation of colon)
- Respiratory distress (difficulty in breathing)
- Respiratory failure (inadequate gas exchange by the respiratory system)
- Alanine aminotransferase increased
- Anaemia (lack of blood)
- Aspartate aminotransferase increased
- Blood bilirubin increased
male:
- Pneumonia
- Pneumonitis (inflammation of the walls of the alveoli in the lungs)
- Haemoglobin decreased
- Pancreatitis acute (sudden inflammation of pancreas)
- Polyomavirus-associated nephropathy (polyomavirus-associated kidney disease)
- Respiratory failure (inadequate gas exchange by the respiratory system)
- White blood cell count decreased
- Febrile neutropenia (fever with reduced white blood cells)
- Bilirubin conjugated increased
- Blood creatinine increased
What are the common drug interactions of Midazolam and Micafungin, by age (0-1 to 60+)? *:
0-1:
- Intraventricular haemorrhage (intraventricular bleeding)
- Bilirubin conjugated increased
- Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
- Retinopathy of prematurity (retina damage in premature)
- Seizure (abnormal excessive or synchronous neuronal activity in the brain)
- White blood cell count increased
- Anaemia (lack of blood)
- Blood creatinine increased
- Hypernatraemia (an abnormally high plasma concentration of sodium ions)
- Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
2-9:
- Haematuria (presence of blood in urine)
- Blood creatine phosphokinase increased
- Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
- Disseminated intravascular coagulation (systemic activation of blood coagulation)
- Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
- Paronychia (infection in the tissues adjacent to a nail on a finger or toe)
- Pharyngitis (inflammation of the pharynx, causing a sore throat)
- Upper respiratory tract infection
- Haemolytic anaemia (anaemia due to haemolysis)
- Renal impairment (severely reduced kidney function)
10-19:
- Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
- Haemoglobin decreased
- Pancreatitis acute (sudden inflammation of pancreas)
- Platelet count decreased
- Polyomavirus-associated nephropathy (polyomavirus-associated kidney disease)
- Renal impairment (severely reduced kidney function)
- White blood cell count decreased
- Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
- Biliary colic
- Candida sepsis (candida in blood stream)
20-29:
- Decreased appetite
- Pyrexia (fever)
- Acquired immunodeficiency syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv))
- Cytomegalovirus infection
- Depressed level of consciousness
- Epstein-barr virus infection
- Hyperbilirubinaemia (excess of bilirubin in the blood)
- Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
- Liver disorder (liver diseases)
- Lymphoma (cancer that begins in immune system cells)
30-39:
n/a
40-49:
- Pneumonia
- Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss)
- Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
- Sepsis (a severe blood infection that can lead to organ failure and death)
- Arrhythmia (irregular heartbeat)
- Bacterial infection
- Blood creatinine increased
- Cardiac failure
- Coagulopathy (blood's ability to clot is impaired)
- Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
50-59:
- Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
- Leukocytosis (increased white blood cells)
- Loss of consciousness
- Pco2 decreased
- Po2 increased
- Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
- Red blood cell count decreased
- Respiratory disorder (respiratory disease)
- Septic shock (shock due to blood infection)
- Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
60+:
- Pneumonia
- Pneumonitis (inflammation of the walls of the alveoli in the lungs)
- Hepatic failure (liver failure)
- Pericardial effusion (fluid around the heart)
- Aphasia (damage to the parts of the brain that control language)
- Bacteraemia (presence of bacteria in the blood)
- Cytomegalovirus viraemia (cytomegalo virus in blood stream)
- Death
- Encephalopathy (functioning of the brain is affected by some agent or condition)
- Fungaemia (fungi circulate in the blood)
What are the existing conditions these people have? *
- Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 13 people, 13.40%
- Sedation: 11 people, 11.34%
- Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 10 people, 10.31%
- High Blood Pressure: 10 people, 10.31%
- Nausea (feeling of having an urge to vomit): 8 people, 8.25%
- Hyperglycemia (high blood sugar): 7 people, 7.22%
- Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 7.22%
- Hiv Infection: 6 people, 6.19%
- Fever: 6 people, 6.19%
- Diabetes: 6 people, 6.19%
* Approximation only. Some reports may have incomplete information.
Do you take Midazolam and Micafungin?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Midazolam (11,246 reports)
- Micafungin (6,562 reports)
Browse all drug interactions of Midazolam and Micafungin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Midazolam:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Micafungin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Midazolam and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Micafungin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Cheng HI, Chen TH, Chung TC, Lee HY, Yu CY, "Micafungin-Induced Hyperbilirubinemia: A Case Report", 臺灣臨床藥學雜誌, 2014 Jun .
- Cheng HI, Chen TH, Chung TC, Lee HY, Yu CY, "Micafungin-Induced Hyperbilirubinemia: A Case Report", 臺灣臨床藥學雜誌, 2014 Jun .
How the study uses the data?
The study uses data from the FDA. It is based on midazolam and micafungin sodium (the active ingredients of Midazolam and Micafungin, respectively), and Midazolam and Micafungin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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