Midazolam and Norco drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Midazolam (midazolam) and Norco (acetaminophen; hydrocodone bitartrate). Common drug interactions include breast cancer metastatic among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Midazolam and Norco. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Midazolam?

Midazolam has active ingredients of midazolam. eHealthMe is studying from 11,246 Midazolam users. Check the latest studies of Midazolam.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

59 people who take Midazolam and Norco together, and have interactions are studied.

What are the common drug interactions of Midazolam and Norco, by gender? *:

female:

Breast cancer metastatic
Cardiovascular disorder (heart diseases)
Coagulopathy (blood's ability to clot is impaired)
Colitis (inflammation of colon)
Cough
Drug ineffective
Electrolyte imbalance
Frequent bowel movements
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heart rate increased

male:

Chronic kidney disease
Sepsis (a severe blood infection that can lead to organ failure and death)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nephrogenic anaemia (anaemia due to kidney disease)
Cough
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypokalaemia (low potassium)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteonecrosis (death of bone)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Midazolam and Norco, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abscess limb (limb infection)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Anaemia (lack of blood)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Chronic kidney disease
Gastric varices
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hospitalisation

30-39:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Septic shock (shock due to blood infection)
Abdominal pain lower
Blood bilirubin increased
Breast cancer metastatic
Cardiovascular disorder (heart diseases)
Coagulopathy (blood's ability to clot is impaired)
Colitis (inflammation of colon)
Cough
Diarrhoea

40-49:

Chronic kidney disease
Nerve injury
Perirectal abscess
Rectal abscess (pus in rectum)
Scar
Sepsis (a severe blood infection that can lead to organ failure and death)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Gas gangrene (bacterial infection that produces gas within tissues)
Groin abscess (pus in groin)
Groin pain

50-59:

Renal failure (kidney dysfunction)
Chronic kidney disease
Hypokalaemia (low potassium)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Cerebral toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii)
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
Vocal cord paralysis
Anaemia (lack of blood)

60+:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Anaemia (lack of blood)
Nausea (feeling of having an urge to vomit)
Postoperative wound infection
Vomiting
Abscess limb (limb infection)
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 23.73%
Diabetes: 14 people, 23.73%
Nausea (feeling of having an urge to vomit): 12 people, 20.34%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 18.64%
Type 2 Diabetes: 9 people, 15.25%
Weight Decreased: 9 people, 15.25%
Hypotension (abnormally low blood pressure): 8 people, 13.56%
Insomnia (sleeplessness): 7 people, 11.86%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 8.47%
Nausea And Vomiting: 5 people, 8.47%

* Approximation only. Some reports may have incomplete information.

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