Midostaurin and Xospata drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Midostaurin (midostaurin) and Xospata (gilteritinib). Common drug interactions include iron overload among females and dermatitis acneiform among males.

The phase IV clinical study analyzes what interactions people have when they take Midostaurin and Xospata. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Midostaurin?

Midostaurin has active ingredients of midostaurin. eHealthMe is studying from 1,137 Midostaurin users. Check the latest studies of Midostaurin.

What is Xospata?

Xospata has active ingredients of gilteritinib. eHealthMe is studying from 2,411 Xospata users. Check the latest studies of Xospata.

On Jul, 06, 2026

20 people who take Midostaurin and Xospata together, and have interactions are studied.

Midostaurin and Xospata drug interactions.

What are the common drug interactions of Midostaurin and Xospata, by gender? *:

female:

Iron overload
Disease progression
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Anaemia macrocytic (a macrocytic class of anaemia)
Blood alkaline phosphatase increased
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Alanine aminotransferase increased

male:

Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Diarrhoea
Hepatic enzyme increased
Folliculitis (infection of hair root)
Graft versus host disease in liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver)
Rash
Splenomegaly (enlargement of spleen)
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Pericarditis (inflammation of the pericardium)
Bacterial infection

What are the common drug interactions of Midostaurin and Xospata, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Diarrhoea
Folliculitis (infection of hair root)
Graft versus host disease in liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver)
Rash
Splenomegaly (enlargement of spleen)
Alanine aminotransferase increased
Blast cell count increased
Liver disorder (liver diseases)

30-39:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Ejection fraction decreased (systolic heart failure)
Monocytosis (an increase in the number of monocytes circulating in the blood)
Nodule (a growth of abnormal tissue)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pulmonary alveolar haemorrhage (acute bleeding)
Subdural haemorrhage (bleeding between the skull and the surface of the brain)

40-49:

Haemoglobin decreased
Neutropenia (an abnormally low number of neutrophils)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Thrombocytopenia (decrease of platelets in blood)

50-59:

Iron overload
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Bacterial infection
Fall
Hepatic enzyme increased

60+:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Disease progression
Skin mass
Acute myeloid leukaemia recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent)
Anaemia macrocytic (a macrocytic class of anaemia)
Blood alkaline phosphatase increased
Pericardial effusion (fluid around the heart)
Pleural effusion (water on the lungs)
Pericarditis (inflammation of the pericardium)
Fatigue (feeling of tiredness)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 9 people, 45.00%
Acute Myeloid Leukaemia Recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent): 3 people, 15.00%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 1 person, 5.00%
Graft Versus Host Disease In Liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver): 1 person, 5.00%
Acute Myelomonocytic Leukaemia (cancer of the blood-forming organs): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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