Milk thistle and Chlorella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Milk thistle (milk thistle) and Chlorella (chlorella). Common drug interactions include alopecia among females and hepatitis toxic among males.

The phase IV clinical study analyzes what interactions people have when they take Milk thistle and Chlorella. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Milk thistle?

Milk thistle has active ingredients of milk thistle. It is often used in fatty liver. eHealthMe is studying from 5,057 Milk thistle users. Check the latest studies of Milk thistle.

What is Chlorella?

Chlorella has active ingredients of chlorella. eHealthMe is studying from 365 Chlorella users. Check the latest studies of Chlorella.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.



On Sep, 03, 2026

16 people who take Milk thistle and Chlorella together, and have interactions are studied.

Milk thistle and Chlorella drug interactions.

What are the common drug interactions of Milk Thistle and Chlorella, by gender? *:

female:

  1. Alopecia (absence of hair from areas of the body)
  2. Anxiety
  3. Aphasia (damage to the parts of the brain that control language)
  4. Confusional state
  5. Depression
  6. Dizziness
  7. Dysphagia (a condition in which swallowing is difficult or painful)
  8. Erythema (redness of the skin)
  9. Insomnia (sleeplessness)
  10. Limb discomfort (discomfort in leg)

male:

  1. Hepatitis toxic
  2. Pruritus (severe itching of the skin)
  3. Tick-borne fever (fever due to tick bite infection)
  4. Anxiety
  5. Arthralgia (joint pain)
  6. Asthenia (weakness)
  7. Benign neoplasm of skin (benign (non-cancerous) tumours of the skin)
  8. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  9. Chest pain
  10. Cold sweat

What are the common drug interactions of Milk Thistle and Chlorella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Erythema (redness of the skin)
  2. Pruritus (severe itching of the skin)
  3. Rash
  4. Skin atrophy (wasting of skin)
  5. Skin disorder (skin disease)
  6. Skin exfoliation (removal of the oldest dead skin cells)
  7. Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

  1. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  2. Platelet count decreased

50-59:

  1. Anxiety
  2. Arthralgia (joint pain)
  3. Benign neoplasm of skin (benign (non-cancerous) tumours of the skin)
  4. Chest pain
  5. Contusion (a type of hematoma of tissue in which capillaries)
  6. Dry eye (lack of adequate tears)
  7. Ear pain
  8. Food allergy
  9. Headache (pain in head)
  10. Insomnia (sleeplessness)

60+:

  1. Hepatitis toxic
  2. Pruritus (severe itching of the skin)
  3. Cold sweat
  4. Confusional state
  5. Depression
  6. Dry mouth
  7. Dysphagia (a condition in which swallowing is difficult or painful)
  8. Erythema (redness of the skin)
  9. Food interaction
  10. Insomnia (sleeplessness)

What are the existing conditions these people have? *

  1. Lung Neoplasm Malignant (cancer tumour of lung): 3 people, 18.75%
  2. Lung Adenocarcinoma (a form of non-small cell lung cancer): 3 people, 18.75%
  3. Drowsiness: 2 people, 12.50%
  4. Prostate Cancer Metastatic: 1 person, 6.25%
  5. Oesophageal Carcinoma (cancer tumour of oesophagus): 1 person, 6.25%
  6. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 6.25%
  7. Fallopian Tube Cancer (cancer of fallopian tube): 1 person, 6.25%
  8. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 6.25%
  9. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 6.25%
  10. Breast Cancer Female: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Milk thistle and Chlorella:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Milk thistle:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Chlorella:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Milk thistle and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Chlorella and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on milk thistle and chlorella (the active ingredients of Milk thistle and Chlorella, respectively), and Milk thistle and Chlorella (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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