Mirapex and Methylphenidate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mirapex (pramipexole dihydrochloride) and Methylphenidate (methylphenidate). Common drug interactions include nerve compression among females and abdominal neoplasm among males.

The phase IV clinical study analyzes what interactions people have when they take Mirapex and Methylphenidate. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Mirapex?

Mirapex has active ingredients of pramipexole dihydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 20,622 Mirapex users. Check the latest studies of Mirapex.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,217 Methylphenidate users. Check the latest studies of Methylphenidate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

45 people who take Mirapex and Methylphenidate together, and have interactions are studied.

Mirapex and Methylphenidate drug interactions.

What are the common drug interactions of Mirapex and Methylphenidate, by gender? *:

female:

Nerve compression
Suicidal ideation
Weight decreased
Hospitalisation
Anxiety
Hypersensitivity
Surgery
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Malaise (a feeling of general discomfort or uneasiness)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

male:

Abdominal neoplasm (cancer of the stomach)
Oesophageal adenocarcinoma (a cancer tumour of an epithelium in oesophagus)
Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)

What are the common drug interactions of Mirapex and Methylphenidate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Back pain
Fall
Hypersensitivity
Ligament injury
Lower respiratory tract infection fungal
Migraine (headache)
Nerve compression
Aphasia (damage to the parts of the brain that control language)
Dependence
Dyskinesia (abnormality or impairment of voluntary movement)

50-59:

Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Suicidal ideation
Surgery
Tooth disorder (tooth disease)
Abdominal neoplasm (cancer of the stomach)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chest pain
Euphoric mood (excessively happy but may become angry or irritable)
Fibromyalgia (a long-term condition which causes pain all over the body)

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Ankle fracture
Hyperhidrosis (abnormally increased sweating)
Oral herpes (viral infection of mouth)
Therapeutic response unexpected
Tooth extraction

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 35 people, 77.78%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 24 people, 53.33%
Drowsiness: 6 people, 13.33%
Pain: 4 people, 8.89%
Breast Cancer Female: 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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