Mirapex and Strattera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mirapex (pramipexole dihydrochloride) and Strattera (atomoxetine hydrochloride). Common drug interactions include increased appetite among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Mirapex and Strattera. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Mirapex?

Mirapex has active ingredients of pramipexole dihydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 20,622 Mirapex users. Check the latest studies of Mirapex.

What is Strattera?

Strattera has active ingredients of atomoxetine hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,324 Strattera users. Check the latest studies of Strattera.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

67 people who take Mirapex and Strattera together, and have interactions are studied.

Mirapex and Strattera drug interactions.

What are the common drug interactions of Mirapex and Strattera, by gender? *:

female:

Increased appetite
Infusion site swelling
Injection site erythema (redness at injection site)
Injection site urticaria (rash of round, red welts on the skin at injection site)
Insomnia (sleeplessness)
Intervertebral disc protrusion (spinal disc protrusion)
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)

male:

Emotional distress
Pathological gambling
Fall
Hallucination, olfactory (sensations of smelling something that is actually not there)
Hypersexuality
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Memory impairment
Psychotic disorder
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypertension (high blood pressure)

What are the common drug interactions of Mirapex and Strattera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Affective disorder (mental disorder)
Aggression

20-29:

n/a

30-39:

Angiopathy (generic term for a disease of the blood vessels)
Blood cholesterol increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Intermittent explosive disorder (behavioural disorder characterized by extreme expressions of anger)
Lung disorder (lung disease)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Optic neuropathy (optic nerve damage)
Papilloedema (optic disc swelling)

40-49:

Pneumonia
Cardiac arrest
Anoxic encephalopathy (brain damage due to lack of oxygen)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Chronic kidney disease
Coma (state of unconsciousness lasting more than six hours)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Ventricular fibrillation (abnormally irregular heart rhythm)

50-59:

Protein s increased
Rash
Simple partial seizures (seizures which affect only a small region of the brain)
Sinus disorder (disease of sinus)
Spinal column stenosis (narrowing of spinal column)
Spinal osteoarthritis (joint cartilage loss in spine)
Splenomegaly (enlargement of spleen)
Tardive dyskinesia (a disorder that involves involuntary movements)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Tenderness (pain or discomfort when an affected area is touched)

60+:

Anxiety
Headache (pain in head)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nasopharyngitis (inflammation of the nasopharynx)
Pain
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Pruritus (severe itching of the skin)
Rash
Acute respiratory failure
Breast cancer

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 32.84%
Pain: 13 people, 19.40%
Insomnia (sleeplessness): 13 people, 19.40%
Depression: 12 people, 17.91%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 13.43%
Parkinson's Disease: 9 people, 13.43%
Stress And Anxiety: 6 people, 8.96%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 8.96%
Genital Herpes (herpes infection of genital): 5 people, 7.46%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 5 people, 7.46%

* Approximation only. Some reports may have incomplete information.

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