Mirapex and Zonegran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mirapex (pramipexole dihydrochloride) and Zonegran (zonisamide). Common drug interactions include impaired gastric emptying among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Mirapex and Zonegran. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Mirapex?

Mirapex has active ingredients of pramipexole dihydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 20,622 Mirapex users. Check the latest studies of Mirapex.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

41 people who take Mirapex and Zonegran together, and have interactions are studied.

What are the common drug interactions of Mirapex and Zonegran, by gender? *:

female:

Impaired gastric emptying
Injection site reaction
Intervertebral disc protrusion (spinal disc protrusion)
Irritable bowel syndrome
Local swelling (swelling at the site of some application of substance or injury)
Drug ineffective
Fall
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Weight increased
Abdominal pain

male:

Death
Anxiety
Intervertebral disc protrusion (spinal disc protrusion)
Pain
Seasonal allergy (allergic condition due to certain season)
Sleep disorder
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bowen's disease (early stage of skin cancer)
Depression

What are the common drug interactions of Mirapex and Zonegran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Death

30-39:

Constipation
Cough
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Impaired gastric emptying
Nausea (feeling of having an urge to vomit)
Retching (strong involuntary effort to vomit)
Abdominal distension
Abdominal pain
Blood glucose increased

40-49:

Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Dizziness
Drug ineffective
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Neuropathy peripheral (surface nerve damage)
Arthropod sting (arthropod bite)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Confusional state

50-59:

Pain
Alopecia (absence of hair from areas of the body)
Drug ineffective
Fatigue (feeling of tiredness)
Infection
Infusion site erythema (reddening of the skin at infusion site)
Infusion site swelling
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Ill-defined disorder

60+:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fall
Drug hypersensitivity
Drug ineffective
Facial bones fracture (bone fracture of face)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypersensitivity
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Intervertebral disc protrusion (spinal disc protrusion)
Local swelling (swelling at the site of some application of substance or injury)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 29.27%
Stress And Anxiety: 7 people, 17.07%
Pain: 7 people, 17.07%
Neuralgia (pain in one or more nerves): 6 people, 14.63%
Muscle Spasms (muscle contraction): 6 people, 14.63%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 14.63%
Ankylosing Spondylitis (type of arthritis affecting the spine): 6 people, 14.63%
Tremor (trembling or shaking movements in one or more parts of your body): 5 people, 12.20%
Sleep Disorder: 5 people, 12.20%
Nausea (feeling of having an urge to vomit): 5 people, 12.20%

* Approximation only. Some reports may have incomplete information.

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