Mirena and Wakix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mirena (levonorgestrel) and Wakix (pitolisant hydrochloride). Common drug interactions include anxiety among females.

The phase IV clinical study analyzes what interactions people have when they take Mirena and Wakix. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Mirena?

Mirena has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 145,266 Mirena users. Check the latest studies of Mirena.

What is Wakix?

Wakix has active ingredients of pitolisant hydrochloride. eHealthMe is studying from 1,982 Wakix users. Check the latest studies of Wakix.

On Jul, 31, 2026

31 people who take Mirena and Wakix together, and have interactions are studied.

What are the common drug interactions of Mirena and Wakix, by gender? *:

female:

Anxiety
Surgery
Cough
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Drug ineffective
Fibromyalgia (a long-term condition which causes pain all over the body)
Fibula fracture
Hunger
Hypermobility syndrome (abnormalities cause abnormal stress on a joint or many joint)
Ill-defined disorder

male:

n/a

What are the common drug interactions of Mirena and Wakix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Drug ineffective
Hunger
Initial insomnia (feeling of inadequate or poor-quality sleep)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Nausea (feeling of having an urge to vomit)
Poor quality sleep
Retching (strong involuntary effort to vomit)
Cataract (clouding of the lens inside the eye)
Pneumonia

30-39:

Anxiety
Blood sodium decreased
Cellulitis (infection under the skin)
Fibula fracture
Hypermobility syndrome (abnormalities cause abnormal stress on a joint or many joint)
Muscle spasms (muscle contraction)
Pulmonary embolism (blockage of the main artery of the lung)
Suicide attempt
Tibia fracture (fracture of lower leg bone)
Blood pressure increased

40-49:

Fibromyalgia (a long-term condition which causes pain all over the body)
Limb injury
Memory impairment
Obesity (having too much body fat)
Suicidal ideation
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 21 people, 67.74%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 38.71%
Drowsiness: 7 people, 22.58%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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