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Moduretic 5-50 and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Moduretic 5-50 (amiloride hydrochloride; hydrochlorothiazide) and Sinemet (carbidopa; levodopa). Common drug interactions include gait disturbance among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Moduretic 5-50 and Sinemet. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Moduretic 5-50?

Moduretic 5-50 has active ingredients of amiloride hydrochloride; hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 3,224 Moduretic 5-50 users. Check the latest studies of Moduretic 5-50.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

On Jul, 10, 2026

30 people who take Moduretic 5-50 and Sinemet together, and have interactions are studied.

Moduretic 5-50 and Sinemet drug interactions.

What are the common drug interactions of Moduretic 5-50 and Sinemet, by gender? *:

female:

  1. Gait disturbance
  2. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  3. Nausea (feeling of having an urge to vomit)
  4. Sedation
  5. Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
  6. Weight decreased
  7. Acute circulatory failure (shock)
  8. Dysarthria (speech disorder)
  9. Hypokalaemia (low potassium)
  10. Hypotension (abnormally low blood pressure)

male:

  1. Anaemia (lack of blood)
  2. Hemiplegia (paralysis of one side of the body)
  3. Pain
  4. Rectal haemorrhage (bleeding from anus)
  5. Renal failure (kidney dysfunction)
  6. Syncope (loss of consciousness with an inability to maintain postural tone)
  7. Urinary tract infection
  8. Abdominal hernia
  9. Abdominal tenderness
  10. Abnormal sleep-related event

What are the common drug interactions of Moduretic 5-50 and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Hyperkalaemia (damage to or disease of the kidney)
  2. Blood creatinine increased
  3. Hallucination (an experience involving the perception of something not present)
  4. Hemiplegia (paralysis of one side of the body)
  5. Hypokalaemia (low potassium)
  6. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  7. Hypotension (abnormally low blood pressure)
  8. Melaena (the passage of black, tarry stools)
  9. Renal failure (kidney dysfunction)
  10. Sedation

* Approximation only. Some reports may have incomplete information.

Do you take Moduretic 5-50 and Sinemet?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Moduretic 5-50 and Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Moduretic 5-50:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Moduretic 5-50 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sinemet and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on amiloride hydrochloride; hydrochlorothiazide and carbidopa; levodopa (the active ingredients of Moduretic 5-50 and Sinemet, respectively), and Moduretic 5-50 and Sinemet (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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