Morphine sulfate and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Morphine sulfate (morphine sulfate) and Rapamune (sirolimus). Common drug interactions include fluid overload among females and small intestinal obstruction among males.

The phase IV clinical study analyzes what interactions people have when they take Morphine sulfate and Rapamune. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Morphine sulfate?

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 87,262 Morphine sulfate users. Check the latest studies of Morphine sulfate.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

On Aug, 06, 2026

40 people who take Morphine sulfate and Rapamune together, and have interactions are studied.

Morphine sulfate and Rapamune drug interactions.

What are the common drug interactions of Morphine Sulfate and Rapamune, by gender? *:

female:

Fluid overload (too much fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hepatic failure (liver failure)
Hypotension (abnormally low blood pressure)
Oedema peripheral (superficial swelling)
Pyrexia (fever)
Right ventricular failure (right half of the heart fails to work)
Septic shock (shock due to blood infection)
Visual impairment
Vomiting

male:

Small intestinal obstruction (blockage in small intestine)
Sepsis (a severe blood infection that can lead to organ failure and death)
Dementia (madness)
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Renal failure acute (rapid kidney dysfunction)

What are the common drug interactions of Morphine Sulfate and Rapamune, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cough
Cyanosis peripheral (blue tint in fingers or extremities, due to inadequate circulation)
Hepatoblastoma (liver cancer)
Pyrexia (fever)

20-29:

Death

30-39:

Abdominal neoplasm (cancer of the stomach)
Abdominal pain
Acute respiratory distress syndrome
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Candidal infection (fungal infection)
Cardiomegaly (increased size of heart than normal)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
General physical health deterioration (weak health status)
Hepatitis cholestatic (flow of bile from the liver is slowed or blocked)
Hepatomegaly (abnormal enlargement of the liver)

40-49:

Dehydration (dryness resulting from the removal of water)
Hyperkalaemia (damage to or disease of the kidney)
Small intestinal obstruction (blockage in small intestine)
Weight decreased
Abdominal pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess (pus)
Acidosis (build-up of carbon dioxide in the blood)
Acute respiratory distress syndrome
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

50-59:

Vascular injury
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Pneumonia
Wound dehiscence (a surgical incision reopens either internally or externally)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Collapse (sudden functional breakdown)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Inflammation
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

Pneumonia
Dyspnoea (difficult or laboured respiration)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Loss of consciousness
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sepsis (a severe blood infection that can lead to organ failure and death)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 10.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 5.00%
Neuropathy Peripheral (surface nerve damage): 2 people, 5.00%
Neuroendocrine Carcinoma Of The Skin (a rare type of cancer that forms on or just beneath the skin, usually in parts of the body that have been exposed to the sun): 2 people, 5.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.00%
Dyslipidaemia (abnormal amount of lipids): 2 people, 5.00%
Depression: 2 people, 5.00%
Cardiac Failure: 2 people, 5.00%
Cardiac Disorder: 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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