Motrin ib and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Motrin ib (ibuprofen) and Melatonin (melatonin). Common drug interactions include palpitations among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Motrin ib and Melatonin. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Motrin ib?

Motrin ib has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 3,772 Motrin ib users. Check the latest studies of Motrin ib.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Aug, 11, 2026

56 people who take Motrin ib and Melatonin together, and have interactions are studied.

Motrin ib and Melatonin drug interactions.

What are the common drug interactions of Motrin Ib and Melatonin, by gender? *:

female:

Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Post procedural infection
Productive cough
Rash
Rash pruritic (redness with itching)
Rhinorrhoea (watery mucus discharge from the nose)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin exfoliation (removal of the oldest dead skin cells)
Somnolence (a state of near-sleep, a strong desire for sleep)

male:

Dehydration (dryness resulting from the removal of water)
Fall
Colitis (inflammation of colon)
Device occlusion
Diarrhoea
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Flushing (the warm, red condition of human skin)
Gastritis (inflammation of stomach)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

What are the common drug interactions of Motrin Ib and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dehydration (dryness resulting from the removal of water)
H1n1 influenza (flu (influenza), which is caused by virus influenza a (h1n1))
Influenza
Aphagia (inability or refusal to swallow)
Colitis (inflammation of colon)
Diarrhoea
Gastritis (inflammation of stomach)
Haematochezia (passage of stools containing blood)
Ileitis (inflammation of the ileum)
Oral disorder (mouth disease)

20-29:

Gastrointestinal disorder (functional problems of gastrointestinal tract)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

30-39:

Hypersensitivity
Peripheral swelling
Urticaria (rash of round, red welts on the skin that itch intensely)
Cerebral haemorrhage (bleeding within the brain)
Fall
Flushing (the warm, red condition of human skin)

40-49:

Aggression
Decreased appetite
Fall
Mood swings (an extreme or rapid change in mood)
Poor quality sleep
Arthralgia (joint pain)
Arthropathy
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Burning sensation
Depression

50-59:

Eye pain
Fall
Dyspnoea (difficult or laboured respiration)
Hip fracture
Post procedural infection
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Upper respiratory tract infection

60+:

Depression
Sleep terror (felling of terror in sleep)
Abscess (pus)
Back pain
Death
Device occlusion
Diarrhoea
Gastric disorder (disease of stomach)
Hyperchlorhydria (gastric acid levels are higher in stomach)
Intestinal haemorrhage (bleeding from intestine)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 16.07%
Sleep Disorder: 8 people, 14.29%
Parkinson's Disease: 7 people, 12.50%
Headache (pain in head): 6 people, 10.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 8.93%
Depression: 5 people, 8.93%
Rectal Fissure (painful condition in which a cut or tear occurs in the anus): 4 people, 7.14%
Otitis Externa (external ear infection): 4 people, 7.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 7.14%
Impaired Gastric Emptying: 4 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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