Mounjaro and Vyvanse drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mounjaro (tirzepatide) and Vyvanse (lisdexamfetamine dimesylate). Common drug interactions include abdominal discomfort among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Mounjaro and Vyvanse. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Mounjaro?

Mounjaro has active ingredients of tirzepatide. It is often used in weight loss. eHealthMe is studying from 37,669 Mounjaro users. Check the latest studies of Mounjaro.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,872 Vyvanse users. Check the latest studies of Vyvanse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

27 people who take Mounjaro and Vyvanse together, and have interactions are studied.

What are the common drug interactions of Mounjaro and Vyvanse, by gender? *:

female:

Abdominal discomfort
Nausea (feeling of having an urge to vomit)
Diarrhoea
Back pain
Hyperhidrosis (abnormally increased sweating)
Injection site urticaria (rash of round, red welts on the skin at injection site)
Intervertebral disc protrusion (spinal disc protrusion)
Vomiting
Constipation
Cough

male:

Abdominal discomfort
Constipation
Injection site abscess
Injection site erythema (redness at injection site)
Injection site pain
Injection site pruritus (severe itching at injection site)
Injection site urticaria (rash of round, red welts on the skin at injection site)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)
Injection site rash

What are the common drug interactions of Mounjaro and Vyvanse, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Irritability
Malaise (a feeling of general discomfort or uneasiness)
Pain
Suicidal ideation
Acne (skin problems that cause pimples)
Complication of device insertion
Dizziness
Erythema (redness of the skin)

40-49:

Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Kidney infection
Nephrolithiasis (calculi in the kidneys)
Psoriasis (immune-mediated disease that affects the skin)
Tardive dyskinesia (a disorder that involves involuntary movements)
Constipation
Gastrointestinal necrosis (destruction of gastrointestinal organ)

50-59:

Abdominal pain upper
Diarrhoea
Drug ineffective
Hunger
Pain
Vomiting

60+:

Abdominal discomfort
Constipation

What are the existing conditions these people have? *

Type 2 Diabetes: 5 people, 18.52%
Weight Decreased: 3 people, 11.11%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 11.11%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 3 people, 11.11%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 11.11%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 7.41%
Immune System Disorder: 2 people, 7.41%
Eosinophilic Esophagitis (Eosinophilic esophagitis (EoE) is an allergic inflammatory condition of the esophagus that involves eosinophils, a type of white blood cell): 2 people, 7.41%
Drowsiness: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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