Movantik and Aleve drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Movantik (naloxegol oxalate) and Aleve (naproxen sodium). Common drug interactions include feeling hot among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Movantik and Aleve. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Movantik?

Movantik has active ingredients of naloxegol oxalate. It is often used in constipation. eHealthMe is studying from 3,523 Movantik users. Check the latest studies of Movantik.

What is Aleve?

Aleve has active ingredients of naproxen sodium. It is often used in pain. eHealthMe is studying from 70,279 Aleve users. Check the latest studies of Aleve.

On Jul, 10, 2026

42 people who take Movantik and Aleve together, and have interactions are studied.

What are the common drug interactions of Movantik and Aleve, by gender? *:

female:

Feeling hot
Flatulence (flatus expelled through the anus)
Foot fracture
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Fungal infection
Gastrointestinal pain
Head injury
Hepatic cyst
Hypoaesthesia (reduced sense of touch or sensation)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Abnormal faeces (abnormal stool)
Air embolism
Anxiety
Back disorder
Balance disorder
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dizziness
Enuresis (repeated inability to control urination)

What are the common drug interactions of Movantik and Aleve, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain upper
Anger
Influenza
Nightmare (unpleasant dream)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Stress
Therapeutic response unexpected
Abdominal discomfort
Blood pressure decreased
Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)

40-49:

n/a

50-59:

Feeling drunk
Flatulence (flatus expelled through the anus)
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Heart rate increased
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Irritable bowel syndrome
Ligament sprain (ligament stretched)
Malaise (a feeling of general discomfort or uneasiness)
Mouth injury
Nervous system disorder (a general class of medical conditions affecting the nervous system)

60+:

Drug ineffective
Dyspnoea (difficult or laboured respiration)
Heart rate increased
Hypersensitivity
Influenza
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Peripheral coldness
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Therapeutic response unexpected

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 23 people, 54.76%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 26.19%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 16.67%
Sleep Disorder: 5 people, 11.90%
Muscle Spasms (muscle contraction): 5 people, 11.90%
Stress And Anxiety: 3 people, 7.14%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 3 people, 7.14%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 7.14%
Hypersensitivity: 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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