Ms contin and Lorcet-hd drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ms contin (morphine sulfate) and Lorcet-hd (acetaminophen; hydrocodone bitartrate). Common drug interactions include formication among females and drug withdrawal syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Ms contin and Lorcet-hd. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Ms contin?

Ms contin has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 69,289 Ms contin users. Check the latest studies of Ms contin.

What is Lorcet-hd?

Lorcet-hd has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 2,221 Lorcet-hd users. Check the latest studies of Lorcet-hd.

On Jul, 05, 2026

46 people who take Ms contin and Lorcet-hd together, and have interactions are studied.

Ms contin and Lorcet-hd drug interactions.

What are the common drug interactions of Ms Contin and Lorcet-Hd, by gender? *:

female:

Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hallucination (an experience involving the perception of something not present)
Sleep disorder
Weight decreased
Disturbance in attention
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pruritus (severe itching of the skin)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Deformity (disfigurement)

male:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Anxiety
Chest discomfort
Chest pain
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dyspepsia (indigestion)
Emotional disorder
Excessive eye blinking (excessive blinking is dry eyes)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)

What are the common drug interactions of Ms Contin and Lorcet-Hd, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diarrhoea
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Abdominal pain
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Depression
Dyskinesia (abnormality or impairment of voluntary movement)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hallucination (an experience involving the perception of something not present)
Sleep disorder

30-39:

Nausea (feeling of having an urge to vomit)
Abdominal abscess (collection of pus in abdomen)
Abdominal pain lower
Asthenia (weakness)
Blood pressure decreased
Dehydration (dryness resulting from the removal of water)
Drug addiction
Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Staphylococcal abscess (pus formation due to staphylococcal bacteria)

40-49:

Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Delusion (a false belief or opinion)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Diarrhoea
Drug abuser
Drug hypersensitivity
Dysarthria (speech disorder)
Dysphonia (speech disorder attributable to a disorder of phonation)

50-59:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Arthralgia (joint pain)
Deformity (disfigurement)
General physical health deterioration (weak health status)
Lichenification (thickening and hardening of the skin)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain in extremity
Peau d'orange (orange peel skin)
Pruritus (severe itching of the skin)

60+:

Arrhythmia (irregular heartbeat)
Asthenia (weakness)
Hypotension (abnormally low blood pressure)
Rib fracture
Sepsis syndrome (a clinical condition of blood infection)
Blood calcium decreased
Blood sodium decreased
Diarrhoea
Fatigue (feeling of tiredness)
Haematocrit decreased

What are the existing conditions these people have? *

Stress And Anxiety: 4 people, 8.70%
Impaired Gastric Emptying: 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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