Msm and Centrum drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Msm (methylsulfonylmethane) and Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include glaucoma among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Msm and Centrum. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Msm?

Msm has active ingredients of methylsulfonylmethane. It is often used in joint pain. eHealthMe is studying from 1,210 Msm users. Check the latest studies of Msm.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

On Aug, 01, 2026

29 people who take Msm and Centrum together, and have interactions are studied.

What are the common drug interactions of Msm and Centrum, by gender? *:

female:

Glaucoma (increased fluid pressure in the eye with vision loss)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Osteoporosis (bones weak and more likely to break)
Back pain
Burning sensation
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Flatulence (flatus expelled through the anus)
Gait disturbance
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Pain
Back disorder
Blood glucose increased
Bruxism (habitual grinding of the teeth, typically during sleep)

What are the common drug interactions of Msm and Centrum, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abdominal pain upper
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Drug ineffective
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Eructation (release of gas from the digestive tract)
Feeling hot
Flatulence (flatus expelled through the anus)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemorrhage (bleeding)
Pain

60+:

Dyspnoea (difficult or laboured respiration)
Oral pain
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Nausea (feeling of having an urge to vomit)
Oropharyngeal pain
Abdominal discomfort
Activities of daily living impaired
Adverse drug reaction
Agitation (state of anxiety or nervous excitement)
Arthropathy

What are the existing conditions these people have? *

Breast Cancer: 5 people, 17.24%
High Blood Pressure: 3 people, 10.34%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 10.34%
Asthma: 3 people, 10.34%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 6.90%
Osteoporosis (bones weak and more likely to break): 2 people, 6.90%
Chest Pain: 2 people, 6.90%
Arthropathy: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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