Mucinex d and Ambien drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mucinex d (guaifenesin; pseudoephedrine hydrochloride) and Ambien (zolpidem tartrate). Common drug interactions include bronchitis among females and injection site pain among males.

The phase IV clinical study analyzes what interactions people have when they take Mucinex d and Ambien. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Mucinex d?

Mucinex d has active ingredients of guaifenesin; pseudoephedrine hydrochloride. It is often used in sinus congestion. eHealthMe is studying from 1,926 Mucinex d users. Check the latest studies of Mucinex d.

What is Ambien?

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. eHealthMe is studying from 93,519 Ambien users. Check the latest studies of Ambien.

On Jul, 28, 2026

45 people who take Mucinex d and Ambien together, and have interactions are studied.

What are the common drug interactions of Mucinex D and Ambien, by gender? *:

female:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fatigue (feeling of tiredness)
Headache (pain in head)
Therapeutic response unexpected
Tooth extraction
Asthma
Injection site pruritus (severe itching at injection site)
Migraine (headache)
Pneumonia
Colitis (inflammation of colon)

male:

Injection site pain

What are the common drug interactions of Mucinex D and Ambien, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Urticaria (rash of round, red welts on the skin that itch intensely)
Abdominal distension
Depression
Dermatitis herpetiformis (chronic blistering skin condition, characterized by blisters filled with a watery fluid)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Pain in extremity
Peripheral swelling
Rash papular (redness with papule)
Rash pruritic (redness with itching)

50-59:

Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Injection site reaction
Oral infection
Pneumonia
Injection site extravasation (flow of (blood or lymph) from injection site)
Injection site pruritus (severe itching at injection site)
Dyspnoea exertional (breathlessness or shortness of breath)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)

60+:

Fall
Colitis (inflammation of colon)
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Depression
Discomfort
Emergency care
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)
Gingival discolouration (discolouration of gums)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 9 people, 20.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 17.78%
Pain: 7 people, 15.56%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 11.11%
Sleep Disorder: 4 people, 8.89%
Dyspnea (difficult or laboured breathing): 4 people, 8.89%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 4 people, 8.89%
Stress And Anxiety: 3 people, 6.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.67%
Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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