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Mucinex d and Trintellix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mucinex d (guaifenesin; pseudoephedrine hydrochloride) and Trintellix (vortioxetine hydrobromide). Common drug interactions include syncope among females and adverse drug reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Mucinex d and Trintellix. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Mucinex d?

Mucinex d has active ingredients of guaifenesin; pseudoephedrine hydrochloride. It is often used in sinus congestion. eHealthMe is studying from 1,926 Mucinex d users. Check the latest studies of Mucinex d.

What is Trintellix?

Trintellix has active ingredients of vortioxetine hydrobromide. It is often used in depression. eHealthMe is studying from 13,067 Trintellix users. Check the latest studies of Trintellix.

On Jul, 17, 2026

16 people who take Mucinex d and Trintellix together, and have interactions are studied.

Mucinex d and Trintellix drug interactions.

What are the common drug interactions of Mucinex D and Trintellix, by gender? *:

female:

  1. Syncope (loss of consciousness with an inability to maintain postural tone)
  2. Vestibular disorder (disorders of the body's balance (vestibular) system in the inner ear)
  3. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  4. Fall
  5. Panic attack
  6. Paralysis
  7. Abdominal pain
  8. Accident
  9. Adverse drug reaction
  10. Drug hypersensitivity

male:

  1. Adverse drug reaction
  2. Cataract (clouding of the lens inside the eye)
  3. Gallbladder operation
  4. Retinal disorder (disease of retina)

What are the common drug interactions of Mucinex D and Trintellix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Dyspnoea (difficult or laboured respiration)
  2. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
  3. Nasopharyngitis (inflammation of the nasopharynx)

40-49:

n/a

50-59:

n/a

60+:

  1. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  2. Fall
  3. Accident
  4. Gallbladder operation
  5. Intervertebral disc degeneration (spinal disc degeneration)
  6. Paralysis

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 56.25%
  2. Insomnia (sleeplessness): 7 people, 43.75%
  3. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 43.75%
  4. Drowsiness: 3 people, 18.75%

* Approximation only. Some reports may have incomplete information.

Do you take Mucinex d and Trintellix?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Mucinex d and Trintellix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Mucinex d:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Trintellix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Mucinex d and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Trintellix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on guaifenesin; pseudoephedrine hydrochloride and vortioxetine hydrobromide (the active ingredients of Mucinex d and Trintellix, respectively), and Mucinex d and Trintellix (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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