Mucinex and Doryx drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mucinex (guaifenesin) and Doryx (doxycycline hyclate). Common drug interactions include deep vein thrombosis among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Mucinex and Doryx. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Mucinex?

Mucinex has active ingredients of guaifenesin. It is often used in cough. eHealthMe is studying from 29,749 Mucinex users. Check the latest studies of Mucinex.

What is Doryx?

Doryx has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 901 Doryx users. Check the latest studies of Doryx.



On Jul, 05, 2026

12 people who take Mucinex and Doryx together, and have interactions are studied.

Mucinex and Doryx drug interactions.

What are the common drug interactions of Mucinex and Doryx, by gender? *:

female:

  1. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  2. Drug ineffective
  3. Pain
  4. Pruritus (severe itching of the skin)
  5. Spinal cord compression
  6. Vitamin d decreased
  7. Oedema peripheral (superficial swelling)
  8. Pain in extremity
  9. Injury
  10. Back pain

male:

  1. Drug ineffective

What are the common drug interactions of Mucinex and Doryx, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  2. Oedema peripheral (superficial swelling)
  3. Pain in extremity
  4. Drug ineffective
  5. Injury

30-39:

n/a

40-49:

n/a

50-59:

  1. Chronic kidney disease

60+:

n/a

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 6 people, 50.00%
  2. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Mucinex and Doryx?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Mucinex and Doryx:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Mucinex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Doryx:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Mucinex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Doryx and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on guaifenesin and doxycycline hyclate (the active ingredients of Mucinex and Doryx, respectively), and Mucinex and Doryx (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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