Mucinex and Hc drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mucinex (guaifenesin) and Hc (hydrocortisone). Common drug interactions include hypertension among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Mucinex and Hc. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Mucinex?

Mucinex has active ingredients of guaifenesin. It is often used in cough. eHealthMe is studying from 29,749 Mucinex users. Check the latest studies of Mucinex.

What is Hc?

Hc has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 1,369 Hc users. Check the latest studies of Hc.

On Jul, 07, 2026

26 people who take Mucinex and Hc together, and have interactions are studied.

What are the common drug interactions of Mucinex and Hc, by gender? *:

female:

Hypertension (high blood pressure)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Infusion site haemorrhage (bleeding from infusion site)
Nephrogenic anaemia (anaemia due to kidney disease)
Nephrolithiasis (calculi in the kidneys)
Overdose
Pulseless electrical activity
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

male:

Diarrhoea
Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
Hypertension (high blood pressure)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Anisocytosis (patient's red blood cells are of unequal size)
Arthralgia (joint pain)
Asthenia (weakness)
Blood pressure diastolic decreased
Blood pressure systolic increased
Body mass index increased

What are the common drug interactions of Mucinex and Hc, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Rash generalised (rash on most of body parts)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Pain
Renal cancer (cancer of kidney)
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Vitamin d deficiency

60+:

Diarrhoea
Haematuria (presence of blood in urine)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Fatigue (feeling of tiredness)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Pain: 9 people, 34.62%
Nausea (feeling of having an urge to vomit): 6 people, 23.08%
Depression: 5 people, 19.23%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 15.38%
Multiple Myeloma (cancer of the plasma cells): 4 people, 15.38%
Itching: 4 people, 15.38%
Hypersensitivity: 4 people, 15.38%
High Blood Pressure: 4 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 15.38%
Serum Ferritin Increased: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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