Mysoline and Duragesic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mysoline (primidone) and Duragesic (fentanyl). Common drug interactions include pain among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Mysoline and Duragesic. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Mysoline?

Mysoline has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 2,849 Mysoline users. Check the latest studies of Mysoline.

What is Duragesic?

Duragesic has active ingredients of fentanyl. eHealthMe is studying from 66,597 Duragesic users. Check the latest studies of Duragesic.

On Jul, 18, 2026

20 people who take Mysoline and Duragesic together, and have interactions are studied.

Mysoline and Duragesic drug interactions.

What are the common drug interactions of Mysoline and Duragesic, by gender? *:

female:

Pain
Adrenocortical insufficiency acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones)
Confusional state
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Arrhythmia (irregular heartbeat)
Fall
Intestinal obstruction
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Small intestinal obstruction (blockage in small intestine)
Cardiac arrest

male:

Back pain
Dizziness
Gait disturbance
Cardiac arrest
Chronic kidney disease
Confusional state
Delirium (wild excitement)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Renal failure (kidney dysfunction)

What are the common drug interactions of Mysoline and Duragesic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Confusional state
Fall
Infusion related reaction
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

50-59:

Delirium (wild excitement)
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Post procedural haemorrhage (post procedural bleeding)
Vomiting
Confusional state
Dizziness
Gait disturbance

60+:

Pain
Back pain
Cardiac arrest
Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Sleep Disorder: 5 people, 25.00%
Pain: 5 people, 25.00%
Muscle Twitching: 4 people, 20.00%
Constipation: 4 people, 20.00%
Abdominal Pain: 4 people, 20.00%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 15.00%
Immunodeficiency Common Variable: 3 people, 15.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 10.00%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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