Mysoline and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mysoline (primidone) and Zide (hydrochlorothiazide). Common drug interactions include osteosclerosis among females and obsessive-compulsive disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Mysoline and Zide. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Mysoline?

Mysoline has active ingredients of primidone. It is often used in essential tremor. eHealthMe is studying from 2,849 Mysoline users. Check the latest studies of Mysoline.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 29, 2026

62 people who take Mysoline and Zide together, and have interactions are studied.

What are the common drug interactions of Mysoline and Zide, by gender? *:

female:

Osteosclerosis (an elevation in bone density)
Pain in jaw
Pancreatitis (inflammation of pancreas)
Pseudoepitheliomatous hyperplasia (type of epithelial hyperplasia associated with chronic inflammatory response)
Renal cyst (kidney cyst)
Scar
Skin cancer
Small intestinal obstruction (blockage in small intestine)
Subcutaneous emphysema (smooth bulging of the skin)
Swelling

male:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pathological gambling
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Abasia (inability to walk)
Activities of daily living impaired
Adverse event
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Angiopathy (generic term for a disease of the blood vessels)

What are the common drug interactions of Mysoline and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood sodium decreased
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Ankylosing spondylitis (type of arthritis affecting the spine)
Drug ineffective
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)

50-59:

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Back disorder
Chills (felling of cold)
Cough
Intervertebral disc disorder (spinal disc disorder)
Malaise (a feeling of general discomfort or uneasiness)
Oxygen saturation decreased
Upper respiratory tract infection
Wheezing (a high-pitched whistling sound made while you breath)
Arthropathy

60+:

Asthenia (weakness)
Dehydration (dryness resulting from the removal of water)
Tremor (trembling or shaking movements in one or more parts of your body)
Actinic keratosis (skin disease due to sun exposure)
Alveolar osteitis (complication of wound healing following extraction of a tooth)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Arthralgia (joint pain)
Arthropathy

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 14.52%
Osteoporosis (bones weak and more likely to break): 8 people, 12.90%
Dyspnea (difficult or laboured breathing): 6 people, 9.68%
Parkinson's Disease: 5 people, 8.06%
Pain: 5 people, 8.06%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 8.06%
Nausea (feeling of having an urge to vomit): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Mysoline and Zide?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously