Nac and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nac (n - acetyl cysteine) and Zide (hydrochlorothiazide). Common drug interactions include fatigue among females and neuropathy peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Nac and Zide. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Nac?

Nac has active ingredients of n - acetyl cysteine. eHealthMe is studying from 857 Nac users. Check the latest studies of Nac.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Aug, 12, 2026

16 people who take Nac and Zide together, and have interactions are studied.

What are the common drug interactions of Nac and Zide, by gender? *:

female:

Fatigue (feeling of tiredness)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug hypersensitivity
Drug ineffective
Ear infection
Femur fracture
Fungal infection
Infusion related reaction
Micturition urgency (urgency to pass the urine)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

male:

Neuropathy peripheral (surface nerve damage)

What are the common drug interactions of Nac and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Axillary mass
Blood lactate dehydrogenase increased
Constipation
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)

50-59:

n/a

60+:

Abdominal discomfort
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Ear infection
Fatigue (feeling of tiredness)
Femur fracture
Fungal infection
Headache (pain in head)
Infusion related reaction
Micturition urgency (urgency to pass the urine)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

What are the existing conditions these people have? *

Pain: 3 people, 18.75%
Blood Pressure Abnormal: 3 people, 18.75%
Gastric Disorder (disease of stomach): 3 people, 18.75%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 18.75%
General Physical Health Deterioration (weak health status): 3 people, 18.75%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 3 people, 18.75%
Herpes Virus Infection: 2 people, 12.50%
High Blood Cholesterol: 2 people, 12.50%
Bacterial Infection: 2 people, 12.50%
Bone Disorder: 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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