Naloxone hydrochloride and Lidocaine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naloxone hydrochloride (naloxone hydrochloride) and Lidocaine (lidocaine). Common drug interactions include blood bicarbonate decreased among females and acute generalised exanthematous pustulosis among males.

The phase IV clinical study analyzes what interactions people have when they take Naloxone hydrochloride and Lidocaine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Naloxone hydrochloride?

Naloxone hydrochloride has active ingredients of naloxone hydrochloride. eHealthMe is studying from 512 Naloxone hydrochloride users. Check the latest studies of Naloxone hydrochloride.

What is Lidocaine?

Lidocaine has active ingredients of lidocaine. It is often used in pain. eHealthMe is studying from 27,555 Lidocaine users. Check the latest studies of Lidocaine.

On Jul, 19, 2026

22 people who take Naloxone hydrochloride and Lidocaine together, and have interactions are studied.

Naloxone hydrochloride and Lidocaine drug interactions.

What are the common drug interactions of Naloxone Hydrochloride and Lidocaine, by gender? *:

female:

Blood bicarbonate decreased
Blood ph decreased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Depressed level of consciousness
Haemoglobin decreased
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Hypotension (abnormally low blood pressure)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Mydriasis (a dilation of the pupil)

male:

Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Streptococcal infection
Unresponsive to stimuli
Blood culture positive
Oropharyngeal pain
White blood cell count decreased
Drug ineffective
Respiratory depression (respiration has a rate below 12 breaths)

What are the common drug interactions of Naloxone Hydrochloride and Lidocaine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cardiogenic shock (inadequate circulation of blood)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)

20-29:

Blood carbon dioxide increased
Blood ph decreased
Dyspnoea (difficult or laboured respiration)
Po2 decreased
Pulmonary oedema (fluid accumulation in the lungs)
Sputum discoloured

30-39:

Blood bicarbonate decreased
Blood ph decreased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Depressed level of consciousness
Haemoglobin decreased
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Mydriasis (a dilation of the pupil)
Nausea (feeling of having an urge to vomit)

40-49:

n/a

50-59:

Drug abuse
Pneumonia bacterial (pneumonia associated with bacterial infection)

60+:

Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Streptococcal infection
Unresponsive to stimuli
Blood culture positive
Oropharyngeal pain
White blood cell count decreased
Drug ineffective
Respiratory depression (respiration has a rate below 12 breaths)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 3 people, 13.64%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 9.09%
High Blood Pressure: 2 people, 9.09%
General Anaesthesia: 2 people, 9.09%
Depression: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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