Naloxone and Aciphex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naloxone (naloxone hydrochloride) and Aciphex (rabeprazole sodium). Common drug interactions include diarrhoea among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Naloxone and Aciphex. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Naloxone?

Naloxone has active ingredients of naloxone hydrochloride. eHealthMe is studying from 6,425 Naloxone users. Check the latest studies of Naloxone.

What is Aciphex?

Aciphex has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 25,301 Aciphex users. Check the latest studies of Aciphex.

On Jul, 20, 2026

21 people who take Naloxone and Aciphex together, and have interactions are studied.

What are the common drug interactions of Naloxone and Aciphex, by gender? *:

female:

Diarrhoea
Pain in extremity
Abdominal pain
Anaemia (lack of blood)
Anxiety
Appendicitis (inflammation of the appendix)
Arthropathy
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Bone pain
Breast cancer recurrent

male:

Abdominal distension
Abdominal pain
Arthropathy
Articular calcification
Asthma
Atrophic vulvovaginitis (inflammation of the vulva)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Bone disorder
Bone pain
Breast cancer recurrent

What are the common drug interactions of Naloxone and Aciphex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Exostosis (formation of new bone on the surface of a bone)
Gingivitis (inflammation of gums)
Herpes zoster
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperlipidaemia (presence of excess lipids in the blood)
Impaired gastric emptying

40-49:

n/a

50-59:

Drug ineffective
Haematochezia (passage of stools containing blood)
Liver disorder (liver diseases)
Menstruation irregular
Muscle spasms (muscle contraction)
Pain in extremity
Polyp
Rash
Tremor (trembling or shaking movements in one or more parts of your body)
Vaginal discharge

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal disorder (kidney disease)
Renal injury (kidney injury)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 13 people, 61.90%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 13 people, 61.90%
Breast Cancer: 12 people, 57.14%
Constipation: 5 people, 23.81%
Diabetes: 5 people, 23.81%
High Blood Cholesterol: 4 people, 19.05%
Asthma: 4 people, 19.05%
Depression: 3 people, 14.29%
Stable Angina (a constant chest pain): 3 people, 14.29%
Infection: 3 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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