Naloxone and Coca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naloxone (naloxone hydrochloride) and Coca (coca). Common drug interactions include bone marrow disorder among females and pulmonary oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Naloxone and Coca. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Naloxone?

Naloxone has active ingredients of naloxone hydrochloride. eHealthMe is studying from 6,425 Naloxone users. Check the latest studies of Naloxone.

What is Coca?

Coca has active ingredients of coca. eHealthMe is studying from 6,072 Coca users. Check the latest studies of Coca.

On Jul, 04, 2026

16 people who take Naloxone and Coca together, and have interactions are studied.

What are the common drug interactions of Naloxone and Coca, by gender? *:

female:

Bone marrow disorder
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Overdose
Substance abuse

male:

Pulmonary oedema (fluid accumulation in the lungs)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Drug level increased
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Electrocardiogram qt prolonged
Electrocardiogram st segment elevation
Encephalopathy (functioning of the brain is affected by some agent or condition)
Facial bones fracture (bone fracture of face)

What are the common drug interactions of Naloxone and Coca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Accidental exposure
Drug screen positive
Drug toxicity
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hyperreflexia (overactive or over responsive reflexes)
Lethargy (tiredness)
Muscle rigidity (muscle stiffness)
Respiratory failure (inadequate gas exchange by the respiratory system)

10-19:

n/a

20-29:

Blood bicarbonate decreased
Drug screen positive
Drug toxicity
Encephalopathy (functioning of the brain is affected by some agent or condition)
Facial bones fracture (bone fracture of face)
Po2 decreased
Suicide attempt
Victim of crime

30-39:

Pulmonary oedema (fluid accumulation in the lungs)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Overdose
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Neonatal respiratory distress syndrome (a serious medical condition where a newborn baby's lungs cannot provide their body with enough oxygen)
Substance abuse

40-49:

Loss of consciousness
Overdose
Sudden death
Unresponsive to stimuli
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Brugada syndrome (life-threatening heart rhythm disorder)
Cardiomegaly (increased size of heart than normal)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Drug level increased
Electrocardiogram qt prolonged

50-59:

Bone marrow disorder
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)

60+:

n/a

What are the existing conditions these people have? *

Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 1 person, 6.25%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 1 person, 6.25%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 1 person, 6.25%
Drug Exposure During Pregnancy: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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