Naloxone and Flagyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naloxone (naloxone hydrochloride) and Flagyl (metronidazole). Common drug interactions include pain in extremity among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Naloxone and Flagyl. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Naloxone?

Naloxone has active ingredients of naloxone hydrochloride. eHealthMe is studying from 6,425 Naloxone users. Check the latest studies of Naloxone.

What is Flagyl?

Flagyl has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 25,897 Flagyl users. Check the latest studies of Flagyl.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

48 people who take Naloxone and Flagyl together, and have interactions are studied.

What are the common drug interactions of Naloxone and Flagyl, by gender? *:

female:

Pain in extremity
Pneumonia
Infection
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Pyrexia (fever)
Abscess (pus)
Anxiety
Chest pain
Deformity (disfigurement)
Intervertebral disc degeneration (spinal disc degeneration)

male:

Anxiety
Pain
Decreased interest
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperlipidaemia (presence of excess lipids in the blood)
Intervertebral disc degeneration (spinal disc degeneration)
Osteolysis (dissolution of bone)
Pain in jaw
Rash
Renal failure acute (rapid kidney dysfunction)

What are the common drug interactions of Naloxone and Flagyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Abnormal behaviour
Acidosis (build-up of carbon dioxide in the blood)
Agitation (state of anxiety or nervous excitement)
Aphasia (damage to the parts of the brain that control language)
Apnoea (suspension of external breathing)
Blood pressure increased
Bradycardia (abnormally slow heart action)
Cardiac arrest
Cardiac failure
Cardiogenic shock (inadequate circulation of blood)

10-19:

Device related infection
Hypokalaemia (low potassium)
Pain in extremity
Pneumonia
Pyrexia (fever)
Aspergillosis (an infection caused by a fungus called aspergillus)
Cardiac arrest
Cardiac failure
Corynebacterium infection (infection by corynebacterium (diphtheria))
Hypoxia (low oxygen in tissues)

20-29:

Abscess limb (limb infection)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Chronic kidney disease
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Orchitis (inflammation of the testes)
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Deformity (disfigurement)
Discomfort
Emotional disorder
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Hyperkeratosis (thickening of the outer layer of the skin)
Joint contracture (a permanent shortening of a muscle or joint)
Muscle contracture (a permanent shortening of a muscle)

40-49:

Anxiety
Chest pain
Decreased interest
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)
Intervertebral disc degeneration (spinal disc degeneration)
Osteolysis (dissolution of bone)
Osteonecrosis of jaw (death of bone of jaw)

50-59:

Blood bilirubin increased
Cardiac disorder
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus inadequate control
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysarthria (speech disorder)
Dystonia (abnormal muscle tone)
Encephalopathy (functioning of the brain is affected by some agent or condition)

60+:

Back pain
Osteosclerosis (an elevation in bone density)
Abscess (pus)
Deformity (disfigurement)
Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
Chest pain
Confusional state
Gait disturbance
Anxiety
Ataxia (loss of full control of bodily movements)

What are the existing conditions these people have? *

Pain: 7 people, 14.58%
Septic Shock (shock due to blood infection): 5 people, 10.42%
Thrombocytopenia (decrease of platelets in blood): 4 people, 8.33%
Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 8.33%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 4 people, 8.33%
Breast Cancer Metastatic: 4 people, 8.33%
Insomnia (sleeplessness): 3 people, 6.25%
High Blood Pressure: 3 people, 6.25%
Diabetes: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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